Gene Ther. 2020 Jan 31

Adeno-associated virus vector enables safe and efficient Cas9 activation in neonatal and adult Cas9 knockin murine cochleae.

Kang W, Zhao X, Sun Z, Dong T, Jin C, Tong L, Zhu W, Tao Y, Wu H

Adeno-associated virus (AAV)-mediated gene delivery systems have been shown to be effective tools for gene manipulation in the inner ear. For example, ... Read More

Source: PubMed

Am. J. Med. Genet. A 2020 Jan 31

Genetic evaluation including exome sequencing of two patients with Gomez-Lopez-Hernandez syndrome: Case reports and review of the literature.

Lindsay F, Anderson I, Wentzensen IM, Suhrbier D, Stevens CA

Rhombencephalosynapsis (RES) is a rare congenital anomaly of the hindbrain characterized by fusion of the cerebellar hemispheres, cerebellar peduncles ... Read More

Source: PubMed

Expert Opin Drug Deliv 2020 Jan 31

Novel drug delivery approaches for the management of hair loss.

Alsalhi WA, Alalola AS, Randolph MJ, Gwillim EC, Tosti A

Introduction: Alopecia is a common clinical complaint for patients and often a source of significant psychological distress. The goal of therapy is to ... Read More

Source: PubMed

Clin. Cancer Res. 2020 Jan 30

FDA Approval Summary: Atezolizumab plus paclitaxel protein-bound for the treatment of patients with advanced or metastatic TNBC whose tumors express PD-L1.

Narayan P, Wahby S, Gao JJ, Amiri-Kordestani L, Ibrahim A, Bloomquist E, Tang S, Xu Y, Liu J, Fu W, Song P, King-Kallimanis BL, Hou S, Gong Y, Kalavar S, Ghosh S, Philip R, Goldberg KB, Theoret MR, Blumenthal GM, Kluetz PG, Sridhara R, Pazdur R, Beaver JA

On March 8, 2019, the FDA granted accelerated approval to atezolizumab in combination with paclitaxel protein-bound for the treatment of adult patient ... Read More

Source: PubMed

J. Anim. Sci. 2020 Jan 30

Physiological response, function of sweat glands, and hair follicle cycling in cattle in response to fescue toxicosis and hair genotype.

Eisemann JH, Ashwell MS, Devine TL, Poole DH, Poore MH, Linder KE

Fescue toxicosis is a syndrome which results when cattle consume toxic endophyte-infected tall fescue. The objective of this study was to compare the ... Read More

Source: PubMed