Drug Toxicity

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Latest Publications and Research on Drug Toxicity

J. Infect.  2018 Jul 12  

Interferon-gamma release assay for tuberculosis screening of solid-organ transplant recipients is cost-effective.

Kowada A

Tuberculosis (TB) is a serious infectious disease with high mortality for solid-organ transplantation. Preventive therapy of latent tuberculosis infec... Read More

Source: PubMed


Mol. Pharm.  2018 Jul 16  

Complexes of Indomethacin with 4-Carbomethoxy-pyrrolidone PAMAM Dendrimers Show Improved Anti-Inflammatory Properties and Temperature Dependent Binding and Release Profile.

Ficker M, Theeuwen MJM, Janaszewska A, Gorzkiewicz M, Svenningsen SW, Klajnert-Maculewicz B, Christensen JB

COX-2 inhibitors such as Non-steroidal anti-inflammatory drugs (NSAIDs) are the most common treatment for chronic inflammatory diseases like arthritis... Read More

Source: PubMed

Expert Opin Drug Metab Toxicol  2018 Jul 16  

An update on expression and function of p-gp/abcb1 and bcrp/abcg2 in the placenta and fetus.

Han LW, Gao C, Mao Q

P-gp/ABCB1 and BCRP/ABCG2 are highly expressed in the placenta and fetus throughout gestation and can modulate exposure and toxicity of drugs and xeno... Read More

Source: PubMed

Regul. Toxicol. Pharmacol.  2018 Jul 12  

Applying a weight of evidence approach to the evaluation of developmental toxicity of biopharmaceuticals.

Rocca M, Morford LL, Blanset DL, Halpern WG, Cavagnaro J, Bowman CJ

Toxicity studies in pregnant animals are not always necessary for assessing the human risk of developmental toxicity of biopharmaceuticals. The growin... Read More

Source: PubMed

Regul. Toxicol. Pharmacol.  2018 Jul 12  

Effects of dietary alpha-linolenic acid-enriched diacylglycerol oil on embryo/fetal development in rats.

Bushita H, Liu S, Ohta T, Ito Y, Saito K, Nukada Y, Ikeda N, Morita O

Recent studies suggest that diets supplemented with alpha-linolenic acid (ALA)-enriched diacylglycerol (DAG) oil provide potential health benefits in ... Read More

Source: PubMed

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