Last Updated on Dec 10, 2019

Latest Publications and Research on Chemical Castration

Cell Biol. Toxicol.  2020 Jan 30  

Regression of castration-resistant prostate cancer by a novel compound QW07 targeting androgen receptor N-terminal domain.

Peng S, Wang J, Chen H, Hu P, He XL, He Y, Wang M, Tang W, He Q, Wang YY, Xie J, Guo D, Ren S, Liu M, Qiu WW, Yi Z

Androgen deprivation therapy (ADT) via surgical or chemical castration frequently fails to halt lethal castration-resistant prostate cancer (CRPC), wh... Read More

Source: PubMed

Asian J. Androl.  2020 Jan 21  

How do we define "castration" in men on androgen deprivation therapy?

Itty S, Getzenberg RH

Androgen deprivation therapy (ADT) is the mainstay for the treatment of advanced prostate cancer. Since the clinical evolution from surgical orchiecto... Read More

Source: PubMed


A novel androgen receptor antagonist JJ-450 inhibits enzalutamide-resistant mutant ARF876L nuclear import and function.

Wu Z, Wang K, Yang Z, Pascal LE, Nelson JB, Takubo K, Wipf P, Wang Z

Castration-resistant prostate cancer can develop resistance to enzalutamide because of androgen receptor (AR) point mutations, AR overexpression, cons... Read More

Source: PubMed

JAMA Oncol  2019 Dec 12  

Overall Survival in Men With Bone Metastases From Castration-Resistant Prostate Cancer Treated With Bone-Targeting Radioisotopes: A Meta-analysis of Individual Patient Data From Randomized Clinical Trials.

Terrisse S, Karamouza E, Parker CC, Sartor AO, James ND, Pirrie S, Collette L, Tombal BF, Chahoud J, Smeland S, Erikstein B, Pignon JP, Fizazi K, Le Teuff G

Both a-emitting and -emitting bone-targeted radioisotopes (RIs) have been developed to treat men with metastatic castration-resistant prostate cancer... Read More

Source: PubMed

Bioorg. Chem.    

Prospective computational design and in vitro bio-analytical tests of new chemical entities as potential selective CYP17A1 lyase inhibitors.

Gumede NJ, Nxumalo W, Bisetty K, Escuder Gilabert L, Medina-Hernandez MJ, Sagrado S

The development and advancement of prostate cancer (PCa) into stage 4, where it metastasize, is a major problem mostly in elder males. The growth of P... Read More

Source: PubMed


@Guest Tuesday, December 5, 2017

I am 80 years old. I have had since 2010 4 TURP operations resulting in a further 3 bladder neck operations. My prostate [BPH] is strangling my urethra again. If I live that long I can look forward to many such operations being needed. Multi visits to the toilet over night, dribble, delays and week flow. Is testosterone the reason for the growth of my Prostate, if so can I seek chemical or even surgical castration. Surely without testosterone the Prostate cannot grow. I think I would like to start a course of chemical castration treatment even if only to ascertain it reducing the Benign Prostate. It may not be permanent? David

Ratnip Tuesday, October 22, 2013

In the USA, I doubt if a doctor would agree unless you probably knew the doctor personally. However, I am a healthy male who decided to chemically castrate myself 7 years ago. I am happy with my decision. I would physically castrate but I love my large testicles. However, I personally a male should physically be castrated at the latest at age 40 and preferably between 30 and 35. He should be chemically castrated in the teen years and continue until physical castration.

Jaqc0 Friday, June 28, 2013

Very interesting. A part from the criminals there are plenty of married or single men, who contemplate chemical castration to lower theirs libidos and there fore theirs sexual frustrations. I wonder if there are differences for theirs effectiveness and also theirs side effects, between the different drugs used for chemical castration. Which one would be more cost effective? Is it possible that after many years that a man may never produce testosterone again when he stops chemical castration? If so how long can he use it before he reaches the point of no return? Is there a difference in effects and side effects between chemical and physical castration? If everything goes well and the man is comfortable with his chemical castration, how long should a man wait before considering physical castration? Would doctors agree to to remove healthy testicles following an extended time on chemical castration? I'd appreciate some answers. Thank

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