Gilbert's syndrome is a common, mild liver disease in which a liver enzyme required to process bilirubin is abnormal. Treatment is not necessary.
Gilbert's syndrome is also known as constitutional hepatic dysfunction, benign unconjugated bilirubinemia and familial nonhemolytic jaundice.
Causes of Gilbertís Syndrome
Gilbertís syndrome is the result of a mutation in a gene for the enzyme UGT1A. Metabolism of bilirubin requires enzymes called UGT glucuronosyl transferases, and UGT1A is one among these. The gene that codes for UGT1A is located on chromosome 2.
A different type of mutation in the same gene is responsible for a more severe and dangerous disease called
Gilbertís syndrome is inherited in an autosomal recessive pattern, i.e. a copy of the defective gene from both parents is required for the child to develop the serious ailment. Many people carry one copy of the abnormal gene. Two abnormal copies are needed for Gilbertís syndrome to develop.
- Harrisonís Principles of Internal Medicine 18th Edition
- The Merck Manual
- Cecil Medicine 24th Edition
Latest Publications and Research on Gilbertís Syndrome
- Glioma patient-reported outcome assessment in clinical care and research: a Response Assessment in Neuro-Oncology collaborative report. - Published by PubMed
- From silos to buckets: a qualitative study of how sexual health clinics address their clients' mental health needs. - Published by PubMed
- Temperature-dependent variation in the extrinsic incubation period elevates the risk of vector-borne disease emergence. - Published by PubMed
- What is an important difference in gait speed in adults with knee osteoarthritis? - Published by PubMed
- Enhanced recovery after surgery with intrathecal opioid in a patient of Gilbert's syndrome undergoing mitral valve replacement. - Published by PubMed