Gilbert's syndrome is a common, mild liver disease in which a liver enzyme required to process bilirubin is abnormal. Treatment is not necessary.
Gilbert's syndrome is also known as constitutional hepatic dysfunction, benign unconjugated bilirubinemia and familial nonhemolytic jaundice.
Causes of Gilbertís Syndrome
Gilbertís syndrome is the result of a mutation in a gene for the enzyme UGT1A. Metabolism of bilirubin requires enzymes called UGT glucuronosyl transferases, and UGT1A is one among these. The gene that codes for UGT1A is located on chromosome 2.
A different type of mutation in the same gene is responsible for a more severe and dangerous disease called
Gilbertís syndrome is inherited in an autosomal recessive pattern, i.e. a copy of the defective gene from both parents is required for the child to develop the serious ailment. Many people carry one copy of the abnormal gene. Two abnormal copies are needed for Gilbertís syndrome to develop.
- Harrisonís Principles of Internal Medicine 18th Edition
- The Merck Manual
- Cecil Medicine 24th Edition
Latest Publications and Research on Gilbertís SyndromeGlobal variation in anastomosis and end colostomy formation following left-sided colorectal resection. - Published by PubMed
[A NEW LOOK AT GILBERT SYNDROME (LITERATURE REVIEW)]. - Published by PubMed
Cored in the act: the use of models to understand core myopathies. - Published by PubMed
Association Between Perfluoroalkyl Substance Exposure and Renal Function in Children With CKD Enrolled in H3Africa Kidney Disease Research Network. - Published by PubMed
Mechanisms of Parenteral Nutrition-Associated Liver and Gut Injury. - Published by PubMed