Complications and Prognosis of Gilbert's Syndrome
Enzyme deficiency in Gilbert’s syndrome may lead to increased side effects of certain drugs. Prognosis is excellent.
Complications
The jaundice produced by Gilbert’s syndrome is mild. However, extremely elevated bilirubin levels may require drugs like phenobarbital.
The enzyme which is abnormal in Gilbert’s syndrome is one that plays a role in clearing a number of medications in the body. Hence its deficiency (as in Gilbert’s syndrome) may lead to increased side effects of certain drugs like:
- Irinotecan, a cancer chemotherapy drug - accumulation of the drug cause severe diarrhoea
- Indinavir: drug used in people with HIV infection
Prognosis
Prognosis (outlook) is excellent.
References:
- Harrison’s Principles of Internal Medicine 18th Edition
- The Merck Manual
- Cecil Medicine 24th Edition
Citations
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APA
Dr. Nithin Jayan. (2014, September 03). Complications and Prognosis of Gilbert’s syndrome. Medindia. Retrieved on May 27, 2022 from https://www.medindia.net/patients/patientinfo/gilberts-syndrome-complications-and-prognosis.htm.
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MLA
Dr. Nithin Jayan. "Complications and Prognosis of Gilbert’s syndrome". Medindia. May 27, 2022. <https://www.medindia.net/patients/patientinfo/gilberts-syndrome-complications-and-prognosis.htm>.
Chicago
Dr. Nithin Jayan. "Complications and Prognosis of Gilbert’s syndrome". Medindia. https://www.medindia.net/patients/patientinfo/gilberts-syndrome-complications-and-prognosis.htm. (accessed May 27, 2022).
Harvard
Dr. Nithin Jayan. 2021. Complications and Prognosis of Gilbert’s syndrome. Medindia, viewed May 27, 2022, https://www.medindia.net/patients/patientinfo/gilberts-syndrome-complications-and-prognosis.htm.
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A very nice article to explain in laymans terms what Gilbert syndrome means. Wish you all could post some downloadable stuff on the same topic.