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Medindia » Health Information » Genetics of Male Infertility - Y-Chromosome Microdeletions

Genetics of Male Infertility - Y-Chromosome Microdeletions

Written by Dr. Reeja Tharu, M.Phil.,Ph.D
Medically Reviewed by The Medindia Medical Review Team on Nov 04, 2016

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Y-Chromosome Microdeletions

AZFb and candidate genes:

AZFb locus spans about 1.5 Mb of the Y chromosome.

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Two important candidate gene families that have been mapped on the AZFb locus are EIF1AY (translation initiation factor 1 A, Y isoform) and RBMY (RNA binding motif on Y).

EIF1AY encodes a ubiquitously expressed translation initiation factor. However it also possesses abundant testis-specific transcripts.

RBMY is a multicopy gene family thought to consist of 30-40 members, some of which are pseudogenes. Numerous RBMY genes have been detected across both arms of the Y chromosome. However, only genes within AZFb, produce detectable levels of the protein. These proteins contain an RNA- binding motif.

Published on Sep 06, 2014
Last Updated on Nov 04, 2016

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Dr. Reeja Tharu. (2016, November 04). Genetics of Male Infertility - Y-Chromosome Microdeletions. Medindia. Retrieved on May 26, 2022 from https://www.medindia.net/patients/patientinfo/gentmaleinfertility_micro3.htm.
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Dr. Reeja Tharu. "Genetics of Male Infertility - Y-Chromosome Microdeletions". Medindia. May 26, 2022. <https://www.medindia.net/patients/patientinfo/gentmaleinfertility_micro3.htm>.
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Dr. Reeja Tharu. "Genetics of Male Infertility - Y-Chromosome Microdeletions". Medindia. https://www.medindia.net/patients/patientinfo/gentmaleinfertility_micro3.htm. (accessed May 26, 2022).
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Dr. Reeja Tharu. 2021. Genetics of Male Infertility - Y-Chromosome Microdeletions. Medindia, viewed May 26, 2022, https://www.medindia.net/patients/patientinfo/gentmaleinfertility_micro3.htm.

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