Estimation of Risks of Genetic Counselling

X- LINKED DOMINANT 

Leprosy

Example 

Familiar hypophosphataemia.

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  • Females - More likely to be affected 
  • No father to son transmission 
  • Lethal in males if Affected 
  • 50% Affected offspring. 

Another the non - Medilan inheritance is called " Mitochondrial Inheritance " 

Non Mendelian Inheritance 

  • Affects only males : Father to son transmission. 
  • Often mutated / altered genes - Fertility genes that assist in normal spermatogenesis – Lead to Male infertility 

Example 

Y - Micro deletions of the A2 F loci. ( A2Fa, A2Fb, A2Fc ) ; but highest incidence with A2FC locus ). - 100% Risk.

Comments

nagarasan Monday, December 28, 2009

I am Nagarasan in India. I am affected with congental myotonia from childhood. What genetic counseling is there for curing this in gene theraphy.

@Guest Thursday, March 5, 2015

Gene therapy is still not an approved therapy in human beings.

However, limited symptomatic treatment may be available.

Also, if you have the genetic confirmation of the disorder, you can potentially prevent the future generation from inheriting the same condition.

Regards,

Dr. Risha Nahar
Genetic Consultant

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