Estimation of Risks of Genetic Counselling

Estimation of Risks of Genetic Counselling

X- LINKED DOMINANT 

Example 

Familiar hypophosphataemia.

FEATURES

• Females - More likely to be affected 
• No father to son transmission 
• Lethal in males if Affected 
• 50% Affected offspring. 

Another the non - Medilan inheritance is called " Mitochondrial Inheritance " 

Non Mendelian Inheritance 

• Affects only males : Father to son transmission. 
• Often mutated / altered genes - Fertility genes that assist in normal spermatogenesis – Lead to Male infertility 

Example 

Y - Micro deletions of the A2 F loci. ( A2Fa, A2Fb, A2Fc ) ; but highest incidence with A2FC locus ). - 100% Risk.