Creator: Dr. Reeja Tharu
Keywords: genetic counseling, genes, Huntington's disease, genetic disorders, infertility,miscarriage, Down's syndrome, DNA, alpha-fetoprotein, pedigree, cytogenic diagnosis, molecular diagnosis, polymerase chain reaction, mendelian inheritance, autosomal recessive,autosomal dominant,X-linked recessive, X-linked dominant,non-mendelian inheritance,polygenic defects, multifactorial inhertance

Written by Dr. Reeja Tharu, M.Phil.,Ph.D
Medically Reviewed by The Medindia Medical Review Team on Sep 18, 2020

Estimation of Risks of Genetic Counselling

X- LINKED DOMINANT

Example

Familiar hypophosphataemia.

FEATURES

Females - More likely to be affected
No father to son transmission
Lethal in males if Affected
50% Affected offspring.

Another the non - Medilan inheritance is called " Mitochondrial Inheritance "

Non Mendelian Inheritance

Affects only males : Father to son transmission.
Often mutated / altered genes - Fertility genes that assist in normal spermatogenesis – Lead to Male infertility

Example

Y - Micro deletions of the A2 F loci. ( A2Fa, A2Fb, A2Fc ) ; but highest incidence with A2FC locus ). - 100% Risk.

Published on Jan 25, 2016
Last Updated on Sep 18, 2020

Comments

nagarasan Monday, December 28, 2009

I am Nagarasan in India. I am affected with congental myotonia from childhood. What genetic counseling is there for curing this in gene theraphy.

@Guest Thursday, March 5, 2015

Gene therapy is still not an approved therapy in human beings.

However, limited symptomatic treatment may be available.

Also, if you have the genetic confirmation of the disorder, you can potentially prevent the future generation from inheriting the same condition.

Regards,

Dr. Risha Nahar
Genetic Consultant

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