Last Updated on Aug 12, 2014

Treatment for Epidermolysis Bullosa

The primary goal of treatment in a case of epidermolysis bullosa is prevention of formation of blisters and related complications. Maximum care has to be taken to avoid skin damage (trauma) and hot environments.

Treatment of EB includes the following:

  • Skin care in EB is of utmost importance. Blistered areas that become crusted or exposed are susceptible to infections. Always consult a doctor, since he may prescribe antibiotic ointments, bandaging, or dressing if required.
  • Swallowing difficulties may require short-term use of steroids. Long-term use is generally not recommended for EB. An infection called candidiasis can occur in the mouth or food pipe requiring antifungal drugs.
  • Maintain good dental hygiene.
  • Nutrition: Excessive skin damage demands extra calories and protein for recovery. Persons with blisters in the mouth or food pipe may have difficulty eating hard foods like nuts or chips. They should stick on to soft food items.
  • Physiotherapy helps to minimize the evolution of contractures, and allows better range of motion.
  • Oral steroids and medications may suppress the immune system, placing the patient at increased risk of infections, and thus should be avoided.
  • Skin grafting is often necessary to replace denuded or ulcerated skin.

Complications of EB may require surgical procedures like:

  • Dilation of the food pipe if there are strictures
  • Repair of hand deformities

Evolving strategies in the treatment of EB include:

  • Protein and gene therapies
  • Transplantation of bone marrow
  • Researches focusing on altering the structural composition of the skin
  • Interferon therapy to fight weakened immunity


  1. A.D.A.M Medical Encyclopedia
  2. Vesicular and bullous diseases. In: Habif TP, ed. Clinical Dermatology. 5th ed. Philadelphia, Pa: Mosby Elsevier;2009;chap 16.
  3. Morelli JG. Vesiculobullous disorders. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, eds. Nelson Textbook of Pediatrics. 18th ed. Philadelphia, Pa: Saunders Elsevier;2007:chap 653.


Navjit Tuesday, October 15, 2013

Is there any treatment for Epidermolysis bullosa [Junctional Variety](Herlitz Variant). Acctually we got one baby before and he got this problem . He was died when he was 11yrs old. We also got one daught she is 7 yrs old and she dont hv any problem she is ok . Now we got new baby Boy . But he got same eb problem. So i want to know if there is any treatment for this. Please reply my post thanks

dr.sankararao Monday, February 25, 2013

i am having a mother with 2 siblings are died of epidermolisis bullosa now the patient is pregnent can any thing can be done to this poor lady pls respond.

dandie1109 Tuesday, February 7, 2012

As U understand, there is NO CURE of any kind! What information indicated a partial cure is available as stated in this article?

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