Diagnosis of Epidermolysis Bullosa
Diagnosis of Epidermolysis Bullosa is done based on a skin biopsy.
Clinical suspicion of epidermolysis bullosa arises based on the appearance of the skin. A diagnosis of epidermolysis bullosa can be confirmed using a number of tests:
Skin biopsy: A sample of skin is taken and subjected to immunofluorescent tests or electron microscopy. Microscopic studies aid the diagnosis of EB.
Special skin tests can help differentiate epidermolysis bullosa acquisita from other forms of EB.
Other tests include:
Blood tests: Poor wound healing may be due to bacterial infections which can be confirmed using blood cultures.
Swallowing or feeding difficulties mandate visual examination using techniques like endoscopy.
- A.D.A.M Medical Encyclopedia
- Vesicular and bullous diseases. In: Habif TP, ed. Clinical Dermatology. 5th ed. Philadelphia, Pa: Mosby Elsevier;2009;chap 16.
- Morelli JG. Vesiculobullous disorders. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, eds. Nelson Textbook of Pediatrics. 18th ed. Philadelphia, Pa: Saunders Elsevier;2007:chap 653.
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