Last Updated on Apr 07, 2014

Diagnosis of Adult-Onset Stillís Disease

Diagnosis of AOSD is confirmed with blood tests and imaging tests.

Adult-onset Stillís disease is complex to diagnose because of the similarity to other diseases such as Crohnís disease, Lyme disease, among others. Certain symptoms of AOSD also resemble cancers such as leukemia and lymphoma. The first step to diagnose AOSD is to take a history along with a medical exam of the patient. The doctor often recommends blood tests to eliminate the possibility of other diseases. Blood tests of patients with AOSD demonstrate the following factors:

  • High levels of C-reactive protein
  • Elevated levels of glycosylated ferritin
  • Elevated levels of white blood cell count and reduced levels of red blood cell count
  • Elevated levels of IL-6, IL-18, INF-°
  • Elevated levels of enzymes of the liver
  • Absence of rheumatoid factor
  • Elevated erythrocyte sedimentation rate (ESR)

Imaging tests (eg, X-rays, ultrasound, CT) identify the extent of damage within the body due to AOSD. Imaging tests can identify the following conditions:

Diagnosis of Adult-Onset Stillís Disease: x-Ray
  • Inflammation of joints
  • Inflammation of the abdomen
  • Enlarged spleen
  • Buildup of fluid between the chest cavity and the lining of lungs (pleural effusion)
  • Inflammation of the lining of the heart (pericarditis)


  1. Adult Still's disease - (
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  3. Persad P, Patel R, Patel N. Adult Onset Stillís Disease and Rocky Mountain Spotted Fever. Case Rep Med. 2010;doi: 10.1155/2010/621046.
  4. Lin KM et al. Formation of Rice Bodies: an Unusual Finding of Adult-Onset Stillís Disease. Clin Rheumatol. 2008;27Suppl2:S55-57.
  5. Lee JB et al. Adult-Onset Stillís Disease with Vesiculopustules on the Hands and Feet. J Korean Med Sci. 2002;17(6):852-855.

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