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Dandy-Walker syndrome (DWS) or Dandy-Walker complex is a congenital brain malformation that involves the cerebellum (an area at the back of the brain that controls movement) and the fluid-filled spaces around it.
Dandy-Walker malformation was first described by Dandy and Blackfan in 1914.
The part of the brain located between the two cerebellar hemispheres called cerebral vermis becomes partially or completely absent. Other key features include an enlargement of the fourth ventricle (one of four connected cavities in the brain) and cyst formation near the internal base of the skull. The three features form a triad.
It is a genetically sporadic disorder. Dandy-Walker syndrome occurs one in every 25,000 live births. Females are mostly affected.
An increase in size and pressure occurs in the fluid spaces surrounding the brain.
The part of the brain located between the two cerebellar hemispheres called cerebral vermis becomes partially or completely absent. Other key features include an enlargement of the fourth ventricle (one of four connected cavities in the brain) and cyst formation near the internal base of the skull. The three features form a triad.
It is a genetically sporadic disorder. Dandy-Walker syndrome occurs one in every 25,000 live births. Females are mostly affected.
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Latest Publications and Research on Dandy Walker Syndrome
Oral-facial-digital syndrome type 1 with hypothalamic hamartoma and dandy-walker malformation. - Published by PubMedNeuropsychological and behavioural phenotype of Dandy--Walker variant presenting in chromosome 22 trisomy: A case study. - Published by PubMed
Central brain herniation in shunted Dandy walker cyst. - Published by PubMed
Anesthetic management of an adolescent with Dandy-Walker syndrome. - Published by PubMed
Aberrant Wnt signalling and cellular over-proliferation in a novel mouse model of Meckel-Gruber syndrome. - Published by PubMed
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