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Clinical Trials Timeline ( 605 BC - 1986 AD )

Written by Vanessa Jones, B.A  | Medically Reviewed by Dr. Sunil Shroff, MBBS, MS, FRCS (UK), D. Urol (Lond) on Apr 22, 2016
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Clinical Trials Timeline ( 605 BC - 1986 AD )

Going down the memory lane of clinical trials is interesting in understanding where we are today. The progress of Science and technology and Pharmokinetics have all contributed to refining and redefining the whole process. The International Conference on Harmonization (ICH) meets from time to time to form and revise guidelines as per Good Clinical Practice.

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605 - 562 BC :

The first clinical trial was carried out by King Nebuchadnezzar II . certain members of the royal family had a diet of bread and water and another group had a diet of meat and wine. It was found that those who consumed bread and water were better nourished and more resplendent than those who stuck to wine and meat.

1537 :

It was by chance that renaissance surgeon Ambroise Pare' treated his patients with a mixture of oil of rose , turpentine and Egg Yolk for treating open wounds compared to the traditionally used formula. He found that the wounds treated with the experimental mixture were not painful whereas those using the traditional formula were found to be swollen and red.

1600 :

Seafarers discovered that by adding oranges and lemons to their diet , there was an improvement in their general health.

1747:

147 years after the discovery made by Seafarers , James Lind conducted the first controlled parallel group clinical trial to prove the effectiveness of Lemon Juice in preventing Scurvy.

19th Century :

Placebo Controlled trials started emerging.

20th Century :

Randomized trials started emerging.

1944:

The introduction of Multicenter studies was seen, where the same trial was conducted at different sites using the same protocol and finally all the centers results were assessed together.

1947:

For the safety and protection of Clinical trial participants , the Nuremberg Codex established a 10 point system .

1964:

The Declaration of Helsinki , was developed by the World Medical Association in order to provide a list of ethical codes for both physicians and participants involed in the clinical trials.

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1986:

The development and Implementation of Good Clinical Practice ( GCP) guidelines in individual countries.

The biological revolution has given rise to many new and promising disciplines such as genomics, proteomics , metabolomines and bioinformatics which is bound to lead to a steady acceleration in drug research and discovery in the years to come.

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ArpitTrivedi

Hi everyone. I need some guidance from all Clinical Research experts. I want to pursue a course : "Masters in Clinical Research : MSCR" offered by ICRI-MUSC. It is a 2 year course, 1st year course by ICRI Global Research and 2nd year course by Medical University of South Carolina. Is this a genuine course or some sort of gamble? Please give your valuable guidance. I have completed my MSc in Biochemistry this year in India.

cresenti


CLINICAL RESEARCH IS ADVANCING DAY BY DAY AS THE NEW FORM OF VIRUSES STAGES ON THIS WORLD EVERY OTHER DAY ... STUDY OF CLINICAL RESEARCH WILL HAVE A GTREAT CAREER

Rahul123

Yes, clinical research is a growing industry in India at the moment. I am a BSc Biochem and want to make my career in this field. I recently joined James Lind Institute for my clinical research course and I hope to get placed somewhere soon.
Rahul Jain

harshit

There is a need of good clinical researcher professionals as India is going to be major hub of clinical trial industry. This can be achieved by educating medical professionals, researchers and graduates on Good Clinical Practice, Ethical conduct of the trial, discouraging fabrication of data and following timelines.

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