Chronic Myeloid Leukemia
Nomenclature: Chronic Myeloid Leukemia, Chronic Myelocytic Leukemia, Chronic Myelogenous Leukemia, CML, Chronic Granulocytic Leukemia
Chronic Myeloid Leukemia is one of the most common types of blood cancer. It is characterized by excess of
Leukemia is a type of
CML is one of the four types of myeloproliferative diseases, that are associated with the overproduction of blood cells within the bone marrow. The other three myeloproliferative diseases are Agnogenic Myeloid Metaplasia (AMM), Polycythemia Rubra Vera (PRV), and Primary Thrombocythemia (PT)
Normally the bone marrow produces immature stem cells that grow and differentiate into the three blood cells type - the
The RBCs carry oxygen and other nutrients to the different body tissues; the WBCs fight off infections and diseases while the platelets are responsible for blood coagulation.
CML is characterized by high levels of abnormal myelocytes (granulocytes) that will never fully mature. These immature white blood cells are labeled myeloid blasts, or myeloblasts. The overproduction of myeloid blasts along with the production of abnormal red blood cells and platelets leaves little room for the production of normal cells.
- SUMMARY OF SPECIFIC SITES OF CANCER - (http://www.canceratlasindia.org/chapter6.asp)
Latest Publications and Research on Chronic Myeloid Leukemia
- Clonal hematopoiesis in hematological disorders. - Published by PubMed
- Histone lysine demethylase KDM5B maintains chronic myeloid leukemia via multiple epigenetic actions. - Published by PubMed
- Correction: CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy. - Published by PubMed
- Distinctive and common features of moderate aplastic anaemia. - Published by PubMed
- Targeting of plasminogen activator inhibitor-1 activity promotes elimination of chronic myeloid leukemia stem cells. - Published by PubMed