Chronic Myeloid Leukemia
Leukemia is a type of cancer that affects the White Blood Cells of the blood and the bone marrow.
Chronic myeloid Leukemia or as popularly known in its abbreviated form - CML, is one of the most common types of leukemia.There are two forms of myeloid leukemia - chronic and acute. The term "Chronic" refers to the CML being a slowly- evolving cancer that may take years to progress unlike the "acute" variety which progresses in a quick manner. "Myeloid" refers to the type of WBC that is produced in an uncontrolled manner.
CML is one of the four types of myeloproliferative diseases, that are associated with the overproduction of blood cells within the bone marrow. The other three myeloproliferative diseases are Agnogenic Myeloid Metaplasia (AMM), Polycythemia Rubra Vera (PRV), and Primary Thrombocythemia (PT)
Normally the bone marrow produces immature stem cells that grow and differentiate into the three blood cells type - the Red Blood Cells (RBC), the White Blood Cells (WBC) and Platelets. These blood cells vary in their morphology and function.
The RBCs carry oxygen and other nutrients to the different body tissues; the WBCs fight off infections and diseases while the platelets are responsible for blood coagulation.
In leukemia, a single WBC stem cell becomes abnormal and undergoes uncontrolled proliferation to manifest as a disease. These leukemic cells can be found in the blood and they course through the body, causing enlargement of the spleen, liver and other organs. There are different types of leukemia depending on the type of WBC they arise from and on the stages that these cells pass through as they mature.
CML is characterized by high levels of abnormal myelocytes (granulocytes) that will never fully mature. These immature white blood cells are labeled myeloid blasts, or myeloblasts. The overproduction of myeloid blasts along with the production of abnormal red blood cells and platelets leaves little room for the production of normal cells.
Latest Publications and Research on Chronic Myeloid LeukemiaContributions of a regional approach to document hematologic disease in Mexico: a 10-year experience in an open population. - Published by PubMed
Inherited THPO mutation, with morphology resembling chronic myeloid leukaemia. - Published by PubMed
Ludwig Boltzmann Cluster Oncology (LBC ONC): first 10 years and future perspectives. - Published by PubMed
Molecular biology as a tool for the treatment of cancer. - Published by PubMed
Myeloid disease mutations of splicing factor SRSF2 cause G2-M arrest and skewed differentiation of human hematopoietic stem and progenitor cells. - Published by PubMed