In Chronic Granulomatous Disease (CGD) the white blood cells are unable to produce activated O2 compounds (or anti-oxidants), which normally help a person to fight against infection. Thus, this leads to recurrent life-threatening bacterial and fungal infections. There occurs an excessive accumulation of immune cells into aggregates called granulomas.
Treatment is with antibiotics, antifungal drugs, and interferon.
The disease was first described in the 1950s as “a fatal granulomatosus of childhood". More than half of cases of chronic granulomatous disease are transmitted genetically as an X-linked recessive trait. CGD thus occurs only in males. Most of the patients with CGD present during the first 5 years of life. In the rest inheritance is autosomal recessive. No racial predilection is known.
Latest Publications and Research on Chronic Granulomatous DiseaseSmall molecule targeting the Rac1-NOX2 interaction prevents collagen-related peptide and thrombin induced reactive oxygen species generation and platelet activation. - Published by PubMed
Pregnancy, child bearing and prevention of giving birth to the affected children in patients with primary immunodeficiency disease; a case-series. - Published by PubMed
Treatment of Madura foot: a systematic review. - Published by PubMed
Pneumoconiosis in a polytetrafluoroethylene (PTFE) spray worker: a case report with an occupational hygiene study. - Published by PubMed
Large-vessel giant cell arteritis: diagnosis, monitoring and management. - Published by PubMed