Blood constantly circulates in blood vessels. The heart pumps oxygen-rich blood, which reaches the different parts of the body through the arteries. It receives oxygen-poor blood from all parts of the body through veins, which it redirects to the lungs to get oxygenated.
Blood contains different types of cells such as red blood cells, white blood cells and platelets, in addition to clotting factors and other proteins.
Clotting of blood is a natural defense mechanism of the body in response to an injury or cut to prevent excessive blood loss. The platelets initially form a plug over the bleeding site, which is reinforced by a mesh formed by the clotting factors.
Sometimes, a clot can form even in the absence of a cut. This often happens when there is damage to the inner lining of the blood vessel or if there is stagnation of blood in a particular part. Some people have genetic or other factors that predispose them to developing blood clots. Clots that form inside large veins result in a condition called deep vein thrombosis. Parts of the clot may break and travel to other organs, resulting in embolism. If the embolus gets lodged in the lungs, the condition is called pulmonary embolism. Sometimes, the clots form in arteries as well.
Signs and symptoms of a blood clot are based on the location of the clot. Arterial clots can cause angina, heart attack, stroke, peripheral arterial disease as well as bloody diarrhea. Venous clots often cause swelling, warmth, redness and pain in the affected limb.
Diagnosis is based on patient history, physical examination and diagnostic tests like blood tests, chest X-ray, electrocardiogram, CT-scan and fluoroscopy. Superficial clots are treated symptomatically with warm compresses and mild medications like acetaminophen or ibuprofen. Deep venous and arterial clots are treated using blood thinners or drugs to break the clots.
Latest Publications and Research on Blood ClotsPreemptively and non-preemptively transplanted patients show a comparable hypercoagulable state prior to kidney transplantation compared to living kidney donors. - Published by PubMed
Venous Thromboembolism in Patients With Spontaneous Intracerebral Hemorrhage: A Multicenter Study. - Published by PubMed
In vitro head-to-head comparison of anticoagulation properties of two heparin brands in a human blood miniature mock loop. - Published by PubMed
Value of ultrasound for access guidance and detection of subclinical vascular complications in the setting of atrial fibrillation cryoballoon ablation. - Published by PubMed
Preemptively and non-preemptively transplanted patients show a comparable hypercoagulable state prior to kidney transplantation compared to living kidney donors. - Published by PubMed