Causes of Bleeding DisordersCauses for bleeding disorders include: Abnormal structure of blood vessels Abnormal production or function of the coagulation factors Antibody development against one or more of the clotting factors Abnormality in the production or functioning of platelet Abnormality in the stability of the blood clot Inherited bleeding disorders caused by a deficiency or dysfunction of a single clotting component. Published on May 02, 2011Last Updated on Feb 17, 2016