Barrett’s esophagus is a condition where the inner lining of the esophagus changes to resemble the intestinal lining. It predisposes the patient to cancer.
The esophagus is a 25 cms tube that connects the throat to the stomach and is the food pipe that lies behind the wind pipe. It consists of muscles lined on the inside by particular type of cells.
Norman Barrett, a British surgeon first described this condition, hence it is named after him. Following Barrett’s esophagus, some cells could show precancerous changes. This stage is called low-grade dysplasia. It could further progress to high-grade dysplasia and cancer.
The exact extent of the disease in the general population is not known since very few studies have been conducted on this topic. From the available information, it is estimated that the disease is less common in Asians than in the Western population.
The rate of patients with Barrett’s esophagus developing cancer is less than 1% per year. Despite this, it is necessary to detect it since esophageal cancer is very difficult to treat once it develops.
- Harrison’s Principles of Internal Medicine 17th edition
- Wood RK and Yang Y. Barrett’s Esophagus in 2008: an Update. Keio J Med 2008; 57 (3): 132-138
- Shalauta MD, Saad R. Barrett’s Esophagus. American Family Physician 2004, 69 (9): 2113-2118
Latest Publications and Research on Barrett’s EsophagusOnce Size May Not Fit All as We Inch Closer to Personalized Management Strategies for Barrett's Esophagus. - Published by PubMed
Screening for esophageal adenocarcinoma and precancerous conditions (dysplasia and Barrett's esophagus) in patients with chronic gastroesophageal reflux disease with or without other risk factors: two systematic reviews and one overview of reviews to inform a guideline of the Canadian Task Force on Preventive Health Care (CTFPHC). - Published by PubMed
Gastrointestinal diseases among relatives of patients with esophageal atresia with or without tracheoesophageal fistula. - Published by PubMed
Barrett's esophagus is a controversial condition. - Published by PubMed
In Barrett's Epithelial Cells, Weakly Acidic Bile Salt Solutions Cause Oxidative DNA Damage with Response and Repair Mediated by p38. - Published by PubMed