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Aplastic Anemia -Treatment & Prognosis

Last Updated on Feb 01, 2016
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Treatment & Prognosis

Aplastic anemia treatment mainly includes medications and multiple blood transfusions.

Mild or moderate aplastic anemia, is usually not life-threatening in which case the patient is not hospitalized. Severe AA, on the other hand, is life threatening and may therefore, require hospitalization.

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Aplastic anemia treatments mainly include medications and multiple blood transfusions.

Blood transfusions merely relieve the signs and symptoms by supplying the blood cells that the body is lacking and cannot induce a complete cure.

Blood transfusions are not without their side effects such as iron overload or antibody production against transfused cells.

In severe cases, bone marrow transplantation (BMT) may be required. Here the non-functional BM from AA patient is destroyed using radiation or chemotherapy and is then replaced with BM, extracted through surgical means, from a matched donor, preferably a sibling. The donorís bone marrow (BM) is intravenously injected into the patientís blood where it migrates to the BM cavities.

This procedure too has its risk as the body may reject the bone marrow and this in turn can lead to life-threatening complications.

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Immunosuppressant Drugs such as cyclosporine (Gengraf, Neoral, Sandimmune) and anti-thymocyte globulin (Thymoglobulin) are often used to treat AA, especially in the case of autoimmune AA.

Corticosteroids, such as methylprednisolone are also given along with immunosuppressants.

Bone marrow stimulants such as filgrastim (Neupogen) and epoetin alfa (Epogen, Procrit) are administered to stimulate the bone marrow to grow new blood cells.

Antibiotics, antivirals are also used in AA treatment.

Aplastic anemia caused by cancer treatment, pregnancy or other drugs is usually short term and the patient can return to normalcy.

If all treatments remain ineffective, aplastic anemia can be fatal.

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Comments

anupam123

my brother has got aplastic anemia with mild bone marrow hypoplasty...which is the best hospital in india/delhi for this

Deepak_93

Is there any sure treatment? My brother suffering with AA from 5 month. Not any treatment work. Even blood transfusion not effective.... Plzzzzzzzzzzz help!!!!!!!!!

123is

hi,,,aap pune k rubi hospital me jaao,, mere dad ka ilaj wahi chal raha hai,,,, mere dad ab thik hai,,,

dukemd69

How is the severity of AA classified: ie. the difference between mild and severe forms? Can a mild form evolve into a severe one? Should women[20s] consider treatments which inhibit their menstrual cycles, in order to reduce blood loss? Are there any "alternative" therapies which are effective; short of BMT or an immunosuppressive regimen?

Spudserella

The difference between mild and sever are the levels at which the blood counts stand. These are the level boundaries to be diagnosed with AA; Haemoglobin <10 g/dL Platelet count < 50 x 109/L Neutrophil count <1.5 x 109/L These are those for severe; Neutrophils <0.5 x 109/L Platelets <20 x 109/L Reticulocytes <20 x 109/L And Very Severe; neutrophils <0.2 x 109/L Women of menstruating age are advised to use drug treatment to either stop of reduce bleeding when platelets stand at less than around 30 but of course every case is individual. There are some cases that have been treated with an immunosupresive drug instead of the chemotherapy option of ALG/ATG along with transfusions but this is generally a treatment for the effects of the illness compared to trying to "cure" it which is the aim of a BMT and ATg/ALG. Hope this helps x

drdoaa

its very help full but i need full text

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