Aplastic Anemia - Diagnosis

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dr. simi paknikar
Medically Reviewed by dr. simi paknikar, MD
Last Updated on Feb 01, 2016
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Diagnosis

Aplastic anemia diagnosis is confirmed through blood tests and bone marrow biopsy.

It is important to take down the history of the patient to understand the nature of work, exposure to chemicals or radiation or if there has been any history of infection.

A physical examination may show the symptoms such as pallor, tachycardia, petechiae, purpura, or ecchymoses. Some show signs of hepatitis.

Aplastic anemia diagnosis may be carried out through blood tests and bone marrow biopsy.

  • Blood Tests- Aplastic anemia is characterized by low number of RBCs, WBCs, and platelets. Low blood cells can be a feature of other diseases in which case it is often confined to one type of cell, as in the case of anemias where the RBC is low. A peripheral blood pancytopenia mostly indicates AA.
  • Bone Marrow Biopsy. Aplastic Anemia diagnosis is usually confirmed by bone marrow biopsy. Here, a small sample of bone marrow is removed using a needle from certain bones of the body, usually the hip bone. This BM sample is then microscopically examined to rule out other blood-related diseases and to confirm AA. The BM of aplastic anemia patients show hypoplasia or very low number of normal cells.

Once AA is confirmed other tests need to be carried out to evaluate the underlying causes of the disorder.

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anupam123

my brother has got aplastic anemia with mild bone marrow hypoplasty...which is the best hospital in india/delhi for this

Is there any sure treatment? My brother suffering with AA from 5 month. Not any treatment work. Even blood transfusion not effective.... Plzzzzzzzzzzz help!!!!!!!!!

123is

hi,,,aap pune k rubi hospital me jaao,, mere dad ka ilaj wahi chal raha hai,,,, mere dad ab thik hai,,,

How is the severity of AA classified: ie. the difference between mild and severe forms? Can a mild form evolve into a severe one? Should women[20s] consider treatments which inhibit their menstrual cycles, in order to reduce blood loss? Are there any "alternative" therapies which are effective; short of BMT or an immunosuppressive regimen?

The difference between mild and sever are the levels at which the blood counts stand. These are the level boundaries to be diagnosed with AA; Haemoglobin <10 g/dL Platelet count < 50 x 109/L Neutrophil count <1.5 x 109/L These are those for severe; Neutrophils <0.5 x 109/L Platelets <20 x 109/L Reticulocytes <20 x 109/L And Very Severe; neutrophils <0.2 x 109/L Women of menstruating age are advised to use drug treatment to either stop of reduce bleeding when platelets stand at less than around 30 but of course every case is individual. There are some cases that have been treated with an immunosupresive drug instead of the chemotherapy option of ALG/ATG along with transfusions but this is generally a treatment for the effects of the illness compared to trying to "cure" it which is the aim of a BMT and ATg/ALG. Hope this helps x

drdoaa

its very help full but i need full text

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