Causes

Causes of primary adrenal insufficiency are: –

Adrenal dysgenesis – when the adrenal glands failed to develop adequately
Impaired steroidogenesis – when the glands are present but are unable to produce cortisol)
Adrenal destruction due to a disease such as:

An autoimmune condition
Infections of the adrenal glands
Cancer metastizing to the adrenal glands
Tuberculosis
Bleeding into the adrenals

The pituitary gland produces the adrenocorticotropic hormone (ACTH), which stimulates the adrenal cortex to produce its hormones. Secondary adrenal insufficiency occurs when the ACTH is produced in inadequate amounts leading to insufficient production of adrenal hormones. This can occur even if the adrenal glands are in good condition.. Secondary adrenal insufficiency also occurs when people who are on corticosteroids (as a part of their treatment for asthma or arthritis) stop taking the supplements abruptly.

Published on Apr 20, 2009
Last Updated on Sep 05, 2014

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