Last Updated on Jun 22, 2020

AML - Causes

Several factors are indicated in AML but the most prominent causes are the chromosomal abnormalities.


Chromosomal Aberrations: Specific chromosomal abnormalities are found in several patients with AML and they are often associated with prognostic significance.

Risk factors: These factors increase a person's chance of getting a disease.

  • Smoking is a proven risk factor for AML. Cancer-causing agents in the tobacco smoke enter the bloodstream and spread to other parts of the body. Smoking causes AML in about 1 in 5 cases.
  • Environmental factors that are linked to acute leukemia are:
    • Long-term exposure to high levels of benzene or other aromatic organic solvents
    • High-dose ionizing radiation exposure also increases the risk.
  • People who had earlier undergone chemotherapy are more likely to develop AML within 9 years after treatment. Some of the important anti-cancer drugs that increases the risk for AML are:
    • Alkylating agents
    • Epipodophyllotoxins
    • Anthracyclines
  • Very few hereditary causes of acute myeloid leukemia are reported
  • The most important risk factor for AML is advancing age.
  • Pre-leukemic disorders, such as myelodysplasia or myeloproliferative disorders are important risk factors.
  • Individuals with congenital conditions like Down Syndrome(DS) and Fanconi Anemia(FA) have increased risk of developing leukemia. The DS individuals have a 10-18 fold increased chance of developing AML.

Comments

PurushNaidu Friday, December 20, 2013

my friend surfing with acute myeloblastic leukemia with maturation. Now he going on chemotherapy. He is on my 2nd session[0, 1 ,2]. Still two more session as per the doctor. Also Doctor's told good progress. I want to know what type of food will add more value to get more immunity. Please give some suggestion on food from nature.

epikia Tuesday, November 27, 2012

Hi.. i am 23 years old diagnose with AML last October 2012 and currently receiving chemotherapy. i am on my 2nd session and my doctor said i will have another session this december. id like to know when they say 5 years survival does that mean i only have 5years left eventhough i take my chemotherapy?

Vikram_Muddya Thursday, November 29, 2012

No, that only means that they certify that your cancer is cured only after 5 years, till then they monitor and see that it doesn't relapse by then.

mehul23 Tuesday, June 12, 2012

78 years aged mother suffering from lukemia pls tell me about the effective medicine and tell me about the chancec or not for recovery.. and which medicine are good for the acute lukemia pls write some medicines name for the recovery for the patitent

chitralekha.ch Tuesday, December 4, 2012

plz take your mother to cancer hospital.the medicine is depends up on the type of leukemia.

Ravikohli Tuesday, February 28, 2012

I have Acute Leukemia[AML] cancer to my sister. Her age is 25 years. In recent test reports Blast are about 80%. Can you please tell me how i can proceed to cure my sister.

Nimat Wednesday, February 2, 2011

Hello.i just read about AML and i am satisfied with the information providede. Though i have one small enquiry; Anthracycline has been listed as one of the drugs given during Chemotherapy that may cause AML in the future and yet it has been listed as a drug for treating AML. Doess it mean that you are at risk of contracting AML again? I will apprecite your assistance on this qustion..

simipaknikar Sunday, February 6, 2011

Anthracyclines have been found to produce AML in patients who underwent treatment for breast cancer and Hodgkin's lymphoma, especially when used with other anticancer drugs and in high doses. Currently anthracyclines are very effective in AML, and the risk of them causing AML are small, hence they are used in AML.

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