About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Acute Lymphoblastic Leukemia

Last Updated on Jun 26, 2020
Font : A-A+

About

Acute lymphoblastic leukemia (ALL) is the commonest of childhood cancers and it has, over the years, served as an ideal cancer research model.

Advertisement

ALL is the commonest of childhood cancers and accounts for almost 25% of all cancers in children below the age of 15 years.

Acute lymphoblastic leukemia has, over the last decade or two, evolved and served as an ideal model for diagnosing and treating cancers in children as well as in adults.

Research and advances has resulted in development of the best combination of chemotherapy that has improved the cure rate, especially in children, to almost 70 to 80%.

What is ALL?

Acute Lymphoblastic Leukemia is a form of blood cancer that is characterized by the abnormal proliferation of the lymphoblasts in the bone marrow and the lymph. ALL has the ability to evolve over a short period of time.

'Acute' refers to the fact that:

  • The disease appears suddenly
  • Is fast- developing, and
  • May quickly spread to other vital organs.
Advertisement

In a healthy individual, the T- cells and B- cells are the two different types of lymphocytes that produce antibodies to fight infections. These lymphocytes are distributed in the blood, lymph nodes, and spleen.

In patients with ALL, the lymphocytes remain immature and are referred to as lymphoblasts. These immature cells rapidly proliferate and outnumber other blood cells in the blood, bone marrow, and lymph tissue.

Acute Lymphoblastic Leukemia

Microscopic view of Acute Lymphoblastic Leukemia

In the majority of ALL cases (85%), the B-cell lymphocytes are affected, while in the rest, the T-cells are altered.

ALL is fatal if left untreated and therefore requires immediate attention. Certain varieties of acute leukemia respond favorably to treatment and several affected individuals are successfully cured. However, there are certain types that do not have a pleasing prognosis.

What is new in Acute Lymphoblastic Leukemia?

1. Chemotherapy-associated Neurocognitive Side Effects Found in Leukemia Patients

Problems with attention, organization and related neurocognitive skills were found develop in the long run, if the young patients who had Leukemia were treated with methotrexate therapy in childhood, finds a new study.

  1. Pui CH. Acute lymphoblastic leukemia. Pediatr Clin North Am 1997; 4: 831-846.
  2. Pui CH, Evans WE. Acute lymphoblastic leukemia. N Engl J Med 1998; 339: 605-615.
  3. Gurney JG, Severson RK, Davis S, Robinson L. Incidence of cancer in children in the United States. Cancer 1995; 75: 2186-2195.
  4. Young J, Gloeckler RL, Silverberg E, Horm J, Miller R. Cancer incidence, survival and mortality for children younger than age 15 years. Cancer 1986; 58: 598-602.

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Dr. Reeja Tharu. (2020, June 26). Acute Lymphoblastic Leukemia - Incidence Causes Symptoms Diagnosis Treatment Prognosis. Medindia. Retrieved on Feb 05, 2023 from https://www.medindia.net/patients/patientinfo/acute-lymphoblastic-leukemia.htm.

  • MLA

    Dr. Reeja Tharu. "Acute Lymphoblastic Leukemia - Incidence Causes Symptoms Diagnosis Treatment Prognosis". Medindia. Feb 05, 2023. <https://www.medindia.net/patients/patientinfo/acute-lymphoblastic-leukemia.htm>.

  • Chicago

    Dr. Reeja Tharu. "Acute Lymphoblastic Leukemia - Incidence Causes Symptoms Diagnosis Treatment Prognosis". Medindia. https://www.medindia.net/patients/patientinfo/acute-lymphoblastic-leukemia.htm. (accessed Feb 05, 2023).

  • Harvard

    Dr. Reeja Tharu. 2021. Acute Lymphoblastic Leukemia - Incidence Causes Symptoms Diagnosis Treatment Prognosis. Medindia, viewed Feb 05, 2023, https://www.medindia.net/patients/patientinfo/acute-lymphoblastic-leukemia.htm.

Latest Publications and Research on Acute Lymphoblastic Leukemia


Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.

Comments

liberty-jasy

I was infected with Hepatitis B for 3 years and i took several drugs prescribed to me from several doctors, but all my effort was wasted as none of the drugs heal me. I cried all day thinking on how i can be cured of this illness, i got outbreaks every 2 weeks. I lost hope while i was looking for solution for my health, one faithful day i was searching the Internet when i came across several testimonies about Dr. Timothy and how he has cured so many infected individual, so i sent a text and ordered the Hepatitis B cure Herbs. Am so happy that just three good weeks of applying the Herbs treatment my Hepatitis B was permanently gone. Address is goodhealthherbalfoundation@yahoo. com or website https://5dc41d5b6d60d.site123.me

winnefrd-helen

manoj.c.p

hi my daughter , rashmi 5 year old female was admitted in a hospital with the c/o fever,and anemia diagnosed as a ALL ,B CELL,started chemotherapy there at the time of admission her haemoglobin is 4,platelet 10,000,peripheral smear shows blast presnt CSF NEGATIVE BONE MARROW NOT DONE induction chemotherapy started prednisolone oral inj.vincristine i.v 4 doses inj, daunorubicin 3 doses inj.L. asparaginase 8 doses IT ,methotrexate 3 times BONE MARRO DONE 3? BLAST SHOWS phase b inj.cyclophosphamide iv 2 time inj,cytarabine s/c [ arac] 4 days * 4 doses tab .6 mp 60 days IT METHOTREXATE 3 times tab.biotraxate RE INDUCTION PHASE tab.dexamethasone orally inj.vincristine iv 4 doses inj. dnr 4 doses inj.L .asparanginase 4 dose inj.cyclophosphamide 1 dose inj.cytarabine 2 dose it.methotrexate 2 doses BONE MARROW DONE SHOWS 3% BLASTS AND 5%LYMPHS CSF NEGATIVE given tab.6pm for one month review 20/8/2012 please given valuable comments how is the condition and what to do next?

satzjeez

DO A HEART PATIENT GET CLL OR ALL OR AML OR CML

Toni95

Non of this has helped me with my research :/ my sister has leukemia and none of the stuff above is even close!!

View More Comments
Advertisement
Recommended Reading
Advertisement
Health Topics A - Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
What's New on Medindia
Is Your House Making You Sick?
Azithromycin may Cause Sudden Cardiac Death
Floppy Iris Syndrome
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close