Acromegaly - Glossary

Written by Dr. Sangamithra, MBBS | Medically Reviewed by The Medindia Medical Review Team  on Sep 05, 2014
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Acromegaly - Glossary

Adenoma - General term for a benign tumor of a gland.

Cardiovascular diseases - Diseases of the heart and/or blood vessels.

Carpal tunnel syndrome - Condition caused by compression of median nerve at the wrist often from repetitive motion.

Computed tomography (CT) scan - An x-ray technique that produces cross-sectional images of tissue structures through the body.

Diabetes mellitus - A chronic syndrome of impaired glucose metabolism due to insufficient secretion or relative deficiency of insulin.

Endocrine system - A regulatory system comprised of the endocrine glands that controls vital body functions such as metabolic activity, growth, and reproduction.

GH receptor agonist (GHRA) - A type of drug that blocks GH action peripherally and decreases IGF-1 production.

Gigantism - A condition caused by excessive secretion of growth hormones in childhood.

Growth hormone (GH) - A substance secreted by the pituitary gland that stimulates growth of bones and soft tissue in children and regulates metabolism in adults.

Hormone - A substance that is secreted by one gland or tissue and transported in blood to act on a distant organ or tissue.

Hypothalamus - Part of the endocrine system that helps activate and control the pituitary.

Headache - Pain or discomfort of the head, upper face, scalp, or neck region.

Impotence - Inability to attain or sustain an erection.

Insulin-like growth factor 1 (IGF-1) - A growth factor made predominantly in the liver; its levels increase in response to increased levels of GH.

Menstrual condition - Any conditions related to menstruation irregularities.

Magnetic resonance imaging (MRI) - A method of obtaining three-dimensional views of body organs using radiofrequency waves and intense magnetic fields.

Oral glucose tolerance test (OGTT) - A test used to assess the body's ability to utilize glucose.

Pituitary - A small gland located at the base of the brain behind the eyes. The pituitary secretes hormones that directly or indirectly affect most basic bodily functions.

Radiotherapy - The use of radiation to kill rapidly growing tumor cells.

Secretion - A substance produced by a tissue that may be retained in the body or released from the body.

Somatostatin - The naturally occurring hormone produced in many parts of the body that signals the pituitary to reduce the production of GH.

Swollen bone - Enlarged, swollen, or misshapen bones.

Tumor - A pathological tissue growth, characterized by uncontrolled multiplication of cells.

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Readers may also be interested to read my summary about the latest guidelines for acromegaly.


I was diagnosed with a pituitary tumor in 2005. It was a late stage macroadenoma. I have had surgery, gamma knife radiation and I have had 2 years of sandostatin. I still never feel good. I have lots of fatigue, muscle weakness and I take a lot of medicine. Can anyone give me any good news on this. My email address is I would love to hear from some other acromegaly patients to hear their stories. Mine has been a nightmare. I was sick and not feeling well for quite sometime, fatigue like no other actually exhaustion to where I was nauseated and sometimes vomiting when I got home from work. Finally told my husband that I either had something wrong with my heart or I had cancer. I was having a lot of palpitations and chest pain so I was sent to a cardiologist my first go around and they didn't pick up on it was going to ablate the areas on my heart that were beating irraticaly. I just need to hear someone elses story. Please email me. Thank you. Kayla

hi Kayla, i too had a macroadenoma which was removed in 06 but did not need drugs however i too have profound fatigue and do not feel good at all. I now have bad joints everywhere and have had 3 total knee replacements and have also got Parkinson's disease. My quality of life is doing down the slippery slope. I am under so many specialists but none seem really interested. It is a lonely battle to get well and sometimes i wonder if i ever will but will not give up! good luck. Where do you live? snurff

You can read longer article here Hope it will help you...

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