Acromegaly - Causes

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Written by Dr. Sangamithra, MBBS | Medically Reviewed by The Medindia Medical Review Team  on Sep 05, 2014
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Acromegaly - Causes

Acromegaly is caused by prolonged overproduction of growth hormones by the pituitary adenoma or a growth that is benign.

Acromegaly is caused by prolonged overproduction of GH by the pituitary gland. In about 90% of Acromegaly patients, the overproduction of GH is caused by a benign tumor of the pituitary gland called an adenoma. These adenomas produce excess GH and produce pressure effect thereby affecting the surrounding brain tissue and optic nerves.

Some adenomas grow slowly and symptoms of excess GH production often go unnoticed for many years, but in case of younger patients the tumor development is aggressive and can be easily detected. Most pituitary tumors arise spontaneously and some from a genetic alteration in a single pituitary cell which leads to increased cell division and GH production.

In a few patients, Acromegaly is caused by tumors of the pancreas, lungs, and adrenal glands. These tumors also lead to an excess of GH or GHRH, the hormone that stimulates the pituitary to make GH. When these non-pituitary tumors are surgically removed, GH levels fall.

Acromegaly - Reference:

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Readers may also be interested to read my summary about the latest guidelines for acromegaly. http://doiop.com/AcromegalyGuidelines

Kayla-S-M

I was diagnosed with a pituitary tumor in 2005. It was a late stage macroadenoma. I have had surgery, gamma knife radiation and I have had 2 years of sandostatin. I still never feel good. I have lots of fatigue, muscle weakness and I take a lot of medicine. Can anyone give me any good news on this. My email address is triplejent@hotmail.com. I would love to hear from some other acromegaly patients to hear their stories. Mine has been a nightmare. I was sick and not feeling well for quite sometime, fatigue like no other actually exhaustion to where I was nauseated and sometimes vomiting when I got home from work. Finally told my husband that I either had something wrong with my heart or I had cancer. I was having a lot of palpitations and chest pain so I was sent to a cardiologist my first go around and they didn't pick up on it was going to ablate the areas on my heart that were beating irraticaly. I just need to hear someone elses story. Please email me. Thank you. Kayla

hi Kayla, i too had a macroadenoma which was removed in 06 but did not need drugs however i too have profound fatigue and do not feel good at all. I now have bad joints everywhere and have had 3 total knee replacements and have also got Parkinson's disease. My quality of life is doing down the slippery slope. I am under so many specialists but none seem really interested. It is a lonely battle to get well and sometimes i wonder if i ever will but will not give up! good luck. Where do you live? snurff

You can read longer article here http://www.genericlook.com/diseases/Acromegaly/. Hope it will help you...

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