Multiple Sclerosis - Causes / Risk Factors

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Causes / Risk Factors

The autoimmune system of the body maybe triggered by a viral infection which then causes multiple sclerosis

Causes

The immune system, which attacks foreign invaders like bacteria and viruses, mistakenly directs its defense cells like the white blood cells and antibodies against the body itself. In the case of Multiple Sclerosis (MS) the protein present in myelin or the insulating material of the nerves is attacked by the antibodies.

This leads to damage of the covering sheath – a process called ‘demyelination’ followed by damage to the nerve itself. When the nerve is damaged, that part of the body served by that nerve is disconnected from the rest of the brain and its functioning is affected. When the area heals, it does so with a scar-giving rise to ‘sclerosis’

1. Genetic - Twins of siblings suffering from MS, children of parents having MS are more likely to get the disease compared to children whose parents who do not suffer from MS.

Though MS is not a hereditary disease the tendency to develop MS is inherited.

2. Viral Infection - A viral infection can produce a protein that resembles myelin. The immune system does not distinguish between the protein of viral origin and the myelin of the nerve fibers and attacks the myelin. In some patients, MS has been known to occur after an attack by a virus called Epstein-Barr virus.

Risk Factors

1. Heredity - People of North European and Caucasian origin seem to be more prone to getting the disease. It is commonly seen in Northern Europe, and North America, but is rare in the Australian Aborigines, the Inuit of Canada, and Maori tribes of New Zealand and in sub-Saharan Africa. The tendency to develop MS is inherited, but the disease may manifest only when environmental triggers are present.

2. Environmental Factors - Infection during a crucial period may lead to conditions conducive to developing MS even as late as a decade later. Interestingly people from tropics who move to temperate climates after the age of 15 years do not show an increased incidence of MS, but those who migrate before the age of 15 have the same risks as a person living in the temperate regions. Stressful life events increased the risk of developing new lesions by 1.6 times.

Lack of Vitamin D has also been suspected as a cause for the disease as it is rare in the tropics.

Triggers of an attack include viral flu or following pregnancy.

References:

  1. Comparison between multiple sclerosis in India and the United States - A case-control study. Bansil S, Singhal BS, Ahuja G K et al. NEUROLOGY 1996; 46: 385-387
  2. Neurology India-vol 47, issue 1 pg12-7, 1999Syal p, Prabhakar S et al

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hii, Me interested in seeking hsct[stem cell transplant] from India.me with rrms 5years post disease activity.Any one who has ms in India would be pyscological help for me.Please responds. Regards shaik

Chronic cerebrospinal venous insufficiency [CCSVI], or the pathological restriction of venous vessel discharge from the CNS has been proposed by Zamboni, et al, as having a correlative relationship to Multiple Sclerosis. From a clinical perspective, it has been demonstrated that the narrowed jugular veins in an MS patient, once widened, do affect the presenting symptoms of MS and the overall health of the patient. It has also been noted that these same veins once treated, restenose after a time in the majority of cases. Why the veins restenose is speculative. One insight, developed through practical observation, suggests that there are gaps in the therapy protocol as it is currently practiced. In general, CCSVI therapy has focused on directly treating the venous system and the stenosed veins. Several other factors that would naturally affect vein recovery have received much less consideration. As to treatment for CCSVI, it should be noted that no meaningful aftercare protocol based on evidence has been considered by the main proponents of the ‘liberation’ therapy (neck venoplasty). In fact, in all of the clinics or hospitals examined for this study, patients weren’t required to stay in the clinical setting any longer than a few hours post-procedure in most cases. Even though it has been observed to be therapeutically useful by some of the main early practitioners of the ‘liberation’ therapy, follow-up, supportive care for recovering patients post-operatively has not seriously been considered to be part of the treatment protocol. To date, follow-up care has primarily centered on when vein re-imaging should be done post-venoplasty. The fact is, by that time, most patients have restenosed (or partially restenosed) and the follow-up Doppler testing is simply detecting restenosis and retrograde flow in veins that are very much deteriorated due to scarring left by the initial procedure. This article discusses a variable approach as to a combination of safe and effective interventional therapies that have been observed to result in enduring venous drainage of the CNS to offset the destructive effects of inflammation and neurodegeneration, and to regenerate disease damaged tissue.

Emma1968

I've was diagnosed with primary progressive ms last week. I've. Had no remissions at all I just get worse. I walk with crutches and suffer extreme exhaustion. I'm currently on a 5 day course of methylphenidate 500mg. I'm fed up of people saying think positively . I can think of nothing to be positive about. My old life has gone and I can't accept this new life. Infant it's not a life it's and existence . I feel a burden to my fiancé and extremely guilty to my children. I have a 5 moth grandson who I can no longer pick up. I'm so so sad. No one understands. My whole family is distraught and I blame myself. I think they'll all be better off without me. Does anybody understand or am I being selfish?

BellaLuna

I am so sorry you feel that way. I too have MS and have been devastated emotionally by the burden but things will change as they always do, so you need to ride the roller coaster for as long as life lets you. No one is ever better off without someone they love!

Nandinin

Will the person suffering from this disease has to take the medicines whole life.

Depends on the medication. Some are having so many side effects that it is not possible to take more than 2 years. But you can be out of it, especially if you are young and in the initial stage, and this without any unwanted side effects.

It is a disease for the whole life, but the treatments are not available, until you search in the right direction for it. It can be cured, as I know a few from them.

I am currently in limbo being tested for MS. I had a brain MRI in April that showed multiple [non-specific]white matter lesions in the sub cortical areas. I have a spinal MRI booked in October. A bit of history: In 2001, I woke up in the middle of the night tried to roll over and couldn't because my right side was numb. By morning I had some feeling and movement back but the side was still week and tingly. Dr ordered a CT scan and said there were no signs of stroke but definitly something neurological. It was left at that. In 2006, I started getting a burning/ tingling feeling in the back of my legs. I had moved so I had a different dr he figured it was sciatica. This would come and go lasting anywhere from a few hours to a week at a time. In 2009, I started having numbness in my toes. It went downhill from there. While camping one day I had a reaction to heat from the sun. My hands and feet started to feel like they were burning. We were at a lake and I had to go sit in the shade. Over the course of the day it got more intense and I started getting weird sensations in my arms electic type pains and even the feeling as if someone was flicking water on my arms. The pain continued to intensify and by the end of the day I could hardly bend my fingers. This lasted 3 days it hurt so bad I even slept on the floor with my hands over the air conditioner. For the next four months I felt aweful. Weak, tired, could hardly walk up the stairs. Pain in my legs especially at night. Pain in my jaw/throaght, headaches, ears ringing,dizzy spells, numbness and tingling. the dr tested me for lupus twice, diabetes twice, porphiria and did like a hundred blood tests all came up negative. I moved back to the town I lived in before a short while later. I felt great for about a year and a half then all of a sudden I started getting the leg pain again. I also started getting tingling and numbness and twitching in my face and eye. My feet and wrists started hurting and going numb, blurry vision in my eye never lasting more then a minute, chest pains, weakness, bladder issues and the scariest was when my legs went numb from the knees to my toes (lasted about 5 hours). It is to the point I had to stop working until they figure out whats going on and treat it. My doc is unsure as to what further testing should be done. Any suggestions or advice is welcomed.

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