Mandibulofacial Dysostosis - Developmental Background

During the developmental stage, the embryo undergoes a series of transformations that form a template for the development of organs and processes.

A group of such processes are responsible for the development of most of the structures involved in the head and neck the branchial arches. These are 6 in number, but essentially five of them are functional as the fifth arch is rudimentary. The first arch is called the mandibular arch and this is the main focus in Treacher Collins syndrome. Defects in this arch lead to the development of the syndrome in future.

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