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Infantile Cortical Hyperostosis - Pathology

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Pathology

This is usually a self-limiting condition. There are several theories as to the pathology of Infantile Cortical Hyperostosis.

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One theory proposes that the condition occurs due to a localized defect during bone formation when blood supply to a particular area is disturbed or deficient. Another theory suggests that Infantile Cortical Hyperostosis is an inherited disorder wherein the small blood vessels that carry blood and nutrients to the particular area of the bone (called arterioles) get necrosed and hence result in the peculiar features of the disease.

Yet another theory proposes that allergy is responsible to cause this disease, but definite proof is not available. An inflammatory focus can also not be ruled out as the cause of this condition.

Some cases of autosomal dominant inheritance have been documented in the early 1980s.

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The condition can mimic like an infection with fever and on blood test can show a raised white cell count. There is usually a tender soft tissue swellings over the collar bone, lower jaw bone and tender. However on pathological examination there are no features of inflammation and they do not go on to form pus like a classical inflammation. When a swelling in one place subside another swelling may appear

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Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.

Comments

aslampasha

my baby sarah fought brilliantly against all odds but she could not tolerate the hospitalized infection(septicemia)and died on 8th nov 09.she was admitted for caffeys symptoms but got infected,drs says this that,but i would say one thing before admission drs should know the patient or else why they have admitted my kid,simply to study the case or they dont want to loose study material.end of the day i have lost my darling.
Sayed Aslam
Hubli
india

aslampasha

Its been 4 months ever since my daughter confirmed with Caffeys,she is on naproxen but no signs of improvement her body weight remains the same ever since her birth,her platelet count is more than 9.50 due to which drs are not giving even steroids which may further worsen her condition.she is been through severe pain and fever due to which she hardly sleeps.

aslampasha

MY BABY GIRL IS CONFIRMED WITH CAFFEYS DISEASE,SHOCKING IS NO FAMILY HISTORY DRS SAYS ITS A GENETIC DISEASE AND BABY IS 3 MONTH OLD IS THERE ANY TREATMENT..........

SAYED ASLAM
HUBLI.
INDIA

thevagi

MY BABY BOY IS HAVING CAFFEY DISEASE, NO FAMILY HISTORY OF CAFFERY, HIS BLOOD TEST SHOWS HIGH HEMOGLOBIN, HIGH PLATELES AND GOANT TROMBOCIATES CELL, HE IS NOW 15 MONTHS, RIGHT RIB , MANDIBLE AND MAXILLE SWELLING, THE SWELLINGIS ALMOST NEARLY ONE YEAR. WHAT TREATMENT DID U GIVE YOUR CHILD

Annie0909

My mother had Caffey disease, I did when I was a child, and now my baby boy also has it. I am very interested to share experiences with other patients...

aslampasha

please let me know the treatment and the time period you all have taken to recover,as my 4 month old baby girl is also suffering from caffeys and her symptoms are very severe.please help me.....

guest

Similar experience-your son is over a year now,how is he getting on?

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