How to Detect Endometrial Cancer by using Endometrial Biopsy?
Women with the following conditions need an endometrial biopsy to detect endometrial cancer.
Postmenopausal Bleeding:
Any woman with postmenopausal bleeding who is not on hormone replacement therapy (HRT) requires endometrial sampling, 7% of women with postmenopausal bleeding are diagnosed of malignancy.
Perimenopausal Bleeding:
Perimenopausal women with abnormal bleeding are at increased risk of endometrial cancer. Thus, all women with abnormal uterine bleeding in the perimenopausal period require endometrial sampling.
Tamoxifen therapy:
Due, to estrogenic effect of Tamoxifen on endometrial lining, patients taking tamoxifen therapy for breast cancer and who experience vaginal bleeding should undergo endometrial biopsy. One of the side effects of breast cancer patients undergoing Tamoxifen therapy is development of endometrial cancer.
Abnormal Pap smear Cytology:
The presence of any endometrial cells on Pap smear in post-menopause women is an indication of significant risk of having endometrial cancer.
Disease follow-up:
Women treated for endometrial cancer by hormonal therapy require a follow-up of endometrial biopsy every 3 to 6 months to ensure the regression of the disease.
