Last Updated on Jun 22, 2016

Staging of Chronic Lymphocytic Leukemia

Staging helps to evaluate the severity of CLL. Based on the size, shape and other cellular morphological features, a specialist classifies the blood cells into specific type and subtype of leukemia.

The Rai system is commonly employed in the United States, while the Binet system is mainly used in Europe.

  • Rai system. Using this system, doctors categorize chronic lymphocytic leukemia into five stages ranging from 0 to 4, with higher numbers indicating the advanced stages of disease. The stages are determined by the RBC and platelet counts and by the presence of an enlarged spleen, liver or lymph nodes.
  • Binet system. Based on this system, chronic lymphocytic leukemia is classified into three stages from A to C, depending on the RBC and platelet counts, and by the number of affected lymphoid regions — such as the neck lymph nodes, groin lymph nodes, spleen and liver.

A summary of the Rai and the Binet system are presented in the table below:

Stage Clinical Features Median Survival
Rai 0 Raised number of lymphocytes (in blood or marrow) >10 years
1 As 0 + enlarged nodes 7 years
2 As 0 + enlarged spleen/liver, =/- enlarged nodes 7 years
3 As 0 + anemia, +/- enlarged nodes, liver or spleen 3-5 years
4 As 0 + low platelets, +/- anemia, enlarged nodes, liver or spleen 3-5 years
Binet A Less than 3 areas of enlarged lymph nodes >10 years
B 3 or more areas of enlarged lymph node 5 years
CAnemia +/- low platelets 3-5 years

Chronic Lymphocytic Leukemia - Reference:


JLD1948 Wednesday, August 22, 2018

Can hyperbaric oxygen therapy be used to treat CLL ?? My Dad is 92 and mild diabetic. He was holding his own until a lymph gland swelled up under his arm; they did radiation; the tumor burst and is now an open wound under his arm. They are doing wound care; three times per week; but it is extremely painful for him. I know that the Hyperbaric treatments are beneficial for numerous wounds and ailments. Could it possibly be beneficial to heal this open would under his arm ?

jen71 Wednesday, July 4, 2012

My dad has been just diagnosed with cll. He is 65 yrs old, a smoker for about 50yrs. now. He said he has not felt right for about 4-5yrs. said he knew something was wrong. His white blood cell count is 280,000 and still fighting shingles. What is his prognosis?

dazedandconfused Monday, April 23, 2012

I'm 48 years old and have had 7 heart attacks in the last 14 years along with 12 stents. Recently I was diagnosed with stage 4 CLL. Can you give me any ideas on life expectancy?

saba_mother Tuesday, July 20, 2010

my mother is diagnosed with CLL, 63 is the count of platelets and 112400 of wbc what are te chances

wanda Tuesday, September 15, 2009

Is CLL hereditary?

John66 Friday, January 11, 2013

Yes, my doctor told me it was. I have CLL and my brother and sister has it.

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