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Prognosis of Chronic Lymphocytic Leukemia

Last Updated on Jun 22, 2016
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Prognosis of Chronic Lymphocytic Leukemia

The prognosis of Chronic Lymphocytic Leukemia (CLL) is rather mixed. Most patients will live for 5 to 10 years. However, some die within 2-3 years of diagnosis.

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In most patients, the disease begins in a benign way followed by a progressive and resistant terminal phase that lasts for 1-2 years. During the latter phase morbidity is high, both due to the disease itself and from the complications that are caused by the therapy.

The prognosis of Chronic Lymphocytic Leukemia may be influenced by -

  • The duration of CLL
  • Stage of the disease
  • Complications that may arise and their outcome
  • Chances for recovery and the time taken to recover
  • Recurrence of the disease
  • General health condition of the patient

The median life–expectancy of patients is as follows-

  • Low-risk group: 14+ years
  • Intermediate risk group: 8 years
  • High–risk group: 4 years

Some of the CLL indicators and their impact on prognosis is given below-

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SNo. INDICATOR PROGNOSTIC IMPLICATIONS
1 <1 yr lymphocyte doubling time Advanced
2 Hb level
<100g/l in women and <110g/l in men

Advanced
3 Bone marrow histology:
-Diffuse
-Non-diffuse

Advanced
Better prognosis
4 Enzyme Zap-70 Advanced
5 Beta2microglobulin
<2.0mg/l
>2.0mg/l

Better prognosis
Advanced
6 IgVH genes
-Mutated
-Unmutated

Better prognosis
Poor prognosis
7 Elevated Lactate Dehydrogenase levels Poor prognosis
8 CD38 expression
<30%
>30%

Better prognosis
Poor prognosis
9 Increased CD23 in blood Advanced state
10 Chromosomal abnormalities like
11qdel,17p del and p53 gene del

Poor prognosis

Chronic Lymphocytic Leukemia - Reference:

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Comments

JLD1948

Can hyperbaric oxygen therapy be used to treat CLL ?? My Dad is 92 and mild diabetic. He was holding his own until a lymph gland swelled up under his arm; they did radiation; the tumor burst and is now an open wound under his arm. They are doing wound care; three times per week; but it is extremely painful for him. I know that the Hyperbaric treatments are beneficial for numerous wounds and ailments. Could it possibly be beneficial to heal this open would under his arm ?

jen71

My dad has been just diagnosed with cll. He is 65 yrs old, a smoker for about 50yrs. now. He said he has not felt right for about 4-5yrs. said he knew something was wrong. His white blood cell count is 280,000 and still fighting shingles. What is his prognosis?

dazedandconfused

I'm 48 years old and have had 7 heart attacks in the last 14 years along with 12 stents. Recently I was diagnosed with stage 4 CLL. Can you give me any ideas on life expectancy?

saba_mother

my mother is diagnosed with CLL, 63 is the count of platelets and 112400 of wbc what are te chances

wanda

Is CLL hereditary?

John66

Yes, my doctor told me it was. I have CLL and my brother and sister has it.

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