Prognosis of Chronic Lymphocytic Leukemia
The prognosis of
In most patients, the disease begins in a benign way followed by a progressive and resistant terminal phase that lasts for 1-2 years. During the latter phase morbidity is high, both due to the disease itself and from the complications that are caused by the therapy.
The prognosis of Chronic Lymphocytic Leukemia may be influenced by -
- The duration of CLL
- Stage of the disease
- Complications that may arise and their outcome
- Chances for recovery and the time taken to recover
- Recurrence of the disease
- General health condition of the patient
The median life–expectancy of patients is as follows-
- Low-risk group: 14+ years
- Intermediate risk group: 8 years
- High–risk group: 4 years
Some of the CLL indicators and their impact on prognosis is given below-
|1||<1 yr lymphocyte doubling time||Advanced|
|2||Hb level |
<100g/l in women and <110g/l in men
|3||Bone marrow histology: |
|6||IgVH genes |
|7||Elevated Lactate Dehydrogenase levels||Poor prognosis|
|8||CD38 expression |
|9||Increased CD23 in blood||Advanced state|
|10||Chromosomal abnormalities like |
11qdel,17p del and p53 gene del
Chronic Lymphocytic Leukemia - Reference:
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Dr. Reeja Tharu. (2016, June 22). Prognosis of Chronic Lymphocytic Leukemia. Medindia. Retrieved on May 19, 2022 from https://www.medindia.net/patients/patientinfo/chronic-lymphocytic-leukemia-prognosis.htm.
Dr. Reeja Tharu. "Prognosis of Chronic Lymphocytic Leukemia". Medindia. May 19, 2022. <https://www.medindia.net/patients/patientinfo/chronic-lymphocytic-leukemia-prognosis.htm>.
Dr. Reeja Tharu. "Prognosis of Chronic Lymphocytic Leukemia". Medindia. https://www.medindia.net/patients/patientinfo/chronic-lymphocytic-leukemia-prognosis.htm. (accessed May 19, 2022).
Dr. Reeja Tharu. 2021. Prognosis of Chronic Lymphocytic Leukemia. Medindia, viewed May 19, 2022, https://www.medindia.net/patients/patientinfo/chronic-lymphocytic-leukemia-prognosis.htm.