Chronic Lymphocytic Leukemia - Diagnosis

Last Updated on Jun 22, 2016
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Chronic Lymphocytic Leukemia - Diagnosis

Most often chronic lymphocytic leukemia is diagnosed accidentally while testing for another medical condition. It can be diagnosed by a simple blood test and by carefully evaluating the symptoms.

Once CLL is suspected, certain specific tests need to be undertaken by the affected individual in order to confirm the diagnosis.

It has now been discovered that there may be at least two types of chronic lymphocytic leukemia. One kind is a smoldering, rather a slow-progressing type, that normally does not require treatment. The other is a more aggressive variety, which is a more serious disease.

With these developments, doctors now believe in doing more tests, besides the conventional blood test, to ascertain the diagnosis. These tests will give the doctor an idea as to the progression of the disease.

The following are some of the diagnostic tests for CLL -

Blood Test- There is an increased number of lymphocytes in patients with CLLca. The number of RBCs and platelets are abnormal too. However, they look normal when seen through the microscope hence further tests, such as Cell Typing or Immunophenotyping, are required to confirm the diagnosis.

Cell typing helps to confirm if the increased number of lymphocytes are caused by cellular reaction to an inflammation or due to cancer. It also helps to identify CLL from other types of leukemia.

Bone Marrow Test- This test is usually done to confirm a diagnosis and to rule out other related diseases. A bone marrow test is not an absolute requisite and is carried out rarely to diagnose CLL.

For this test, a small amount of bone marrow is aspirated from the pelvic bone or sternum (breast bone) using a needle. Local anesthesia is employed to carry out the procedure. The aspirated sample is observed under the microscope to check for abnormal cells. It can also be used for other tests, such as cell typing or cytogenetic testing.

Cytogenetic Tests- These tests are carried out to detect changes, such as the deletion or a translocation, in the chromosomes. Special techniques, like Fluorescent In Situ Hybridization (FISH), detect chromosomal abnormalities associated with CLL that a standard technique is unable to identify. These tests also help to predict the prognosis of the disease.

Certain substances in the individual may indicate a more severe form of the disease. These are high amounts of the proteins ZAP-70, immunoglobulin mutation status or CD38.

Other tests, such as chest x-ray, are performed to assess the overall health status of the individual.

Chronic Lymphocytic Leukemia - Reference:

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Can hyperbaric oxygen therapy be used to treat CLL ?? My Dad is 92 and mild diabetic. He was holding his own until a lymph gland swelled up under his arm; they did radiation; the tumor burst and is now an open wound under his arm. They are doing wound care; three times per week; but it is extremely painful for him. I know that the Hyperbaric treatments are beneficial for numerous wounds and ailments. Could it possibly be beneficial to heal this open would under his arm ?


My dad has been just diagnosed with cll. He is 65 yrs old, a smoker for about 50yrs. now. He said he has not felt right for about 4-5yrs. said he knew something was wrong. His white blood cell count is 280,000 and still fighting shingles. What is his prognosis?

I'm 48 years old and have had 7 heart attacks in the last 14 years along with 12 stents. Recently I was diagnosed with stage 4 CLL. Can you give me any ideas on life expectancy?


my mother is diagnosed with CLL, 63 is the count of platelets and 112400 of wbc what are te chances

Yes, my doctor told me it was. I have CLL and my brother and sister has it.

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