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Indications for undertaking tests for Cardiac Markers

Last Updated on Jul 04, 2018
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Indications for undertaking tests for Cardiac Markers

Cardiac markers play a key role in the diagnosis, risk stratification, and treatment of patients with chest pain and suspected acute coronary syndrome (ACS).

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Cardiac markers (cardiac troponin, in particular) have been incorporated in to the new definition of acute myocardial infarction. Apart from these, cardiac markers are also indicated in cases of chronic renal failure and non ischaemic heart disease. Sub arachnoid haemorrhage and pulmonary embolism are associated with elevated marker levels (TnI and TnT respsectively).

References:

  1. Cecil Medicine, 23rd Ed. Harrison's PRINCIPLES OF INTERNAL MEDICINE, 17TH Edition
  2. Cardiovasc Pathol. 2007 Nov-Dec;16(6):329-35. Epub 2007 Jun 20.
  3. INTERNATIONAL JOURNAL OF CLINICAL & LABORATORY RESEARCH Volume 29, Number 2, 56-63, DOI: 10.1007/s005990050064

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Randox

The ischemic biomarker Heart-type Fatty Acid Binding Protein [H-FABP] can substantially improve the detection of high risk patients when Troponin-negative, even when a high sensitivity assay is used, a new publication has shown. In the June edition of JACC, Professor Alistair Hall and colleagues from the University of Leeds, UK, prospectively studied a cohort of 1080 consecutive patients admitted to hospital with suspected ACS and compared the H-FABP assay (Randox Laboratories) with the high sensitivity Ultra-TnI assay (Siemens Healthcare Diagnostics).

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