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Cardiac Marker genes

Last Updated on Jul 04, 2018
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‘Cardiac marker genes are thought to participate in cardiomyocyte differentiation and to contribute to heart hypertrophy in animal models’, says the results published in Cardiovasc Pathol.2007 Nov-Dec;16(6):329-35. Epub 2007 Jun 20.

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Early cardiac marker genes include: cardiac-specific homeobox (Csx/Nkx2.5), myocardin, homeodomain only protein, GATA4, and myocyte enhancer factor 2C. Altered expressions of early cardiac marker genes and differentiation-specific marker genes have been found in patients with the condition called hypertrophic cardiomyopathy.

References:

  1. Cecil Medicine, 23rd Ed. Harrison's PRINCIPLES OF INTERNAL MEDICINE, 17TH Edition
  2. Cardiovasc Pathol. 2007 Nov-Dec;16(6):329-35. Epub 2007 Jun 20.
  3. INTERNATIONAL JOURNAL OF CLINICAL & LABORATORY RESEARCH Volume 29, Number 2, 56-63, DOI: 10.1007/s005990050064

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Randox

The ischemic biomarker Heart-type Fatty Acid Binding Protein [H-FABP] can substantially improve the detection of high risk patients when Troponin-negative, even when a high sensitivity assay is used, a new publication has shown. In the June edition of JACC, Professor Alistair Hall and colleagues from the University of Leeds, UK, prospectively studied a cohort of 1080 consecutive patients admitted to hospital with suspected ACS and compared the H-FABP assay (Randox Laboratories) with the high sensitivity Ultra-TnI assay (Siemens Healthcare Diagnostics).

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