| YEAR | MILESTONES |
| 2700 BC | Shen Nung the second Chinese emperor who had tested the effects of 300 drugs on himself and has explained the narcotic properties of the Kemp plant. |
| 1350 BC | The soporific and aphrodisiac properties of the mandrake were well known among the Egyptian Pharaohs. |
| 77 AD | Dioscorides Pedanius a Greek physician in his fourth book of Materia Medica has gives details about the various substances that induces anesthesia. He coined the term anesthesia meaning lack of sensation in Greek. |
| 1037 | Avicenna an Iranian philosopher and physician said that the most powerful stupefacient is opium |
| 1460 | Heinrich von Pfolsprundt, a German military surgeon was the first to give an account of the soporific sponge (a recipe that suppresses sensation of pain) used in the treatment of gunshots. |
| 1665 | Sir Christopher Wren an English Architect with the help of Robert Boyle was the first to infuse opium and perform intravenousanesthesia in dogs. |
| 1765 | Matthew Turner an English chemist and surgeon was the first person to produce and sell ether. He recommended inhalation of sulfuric ether as a treatment for headaches. |
| 1772 | Joseph Priestley an English chemist discovered nitrous oxide. |
| 1786 | Cornelius Celsus described in detail about the preparation of the anodyne pills in the 46th edition of the Roman encyclopedia. |
| 1817 | Friedrich Serturner a German apothecary coined the term morphine and also elucidated the narcotic properties of opium. |
| 1834 | Jean Baptiste Dumas a French chemist unraveled the chemical structure and coined the term chloroform. |
| 1847 | Marie Jean Pierre Flourens and Francois-Achille Longet reported the effects and mode of action of ether on the central nervous system. |
| 1847 | Sir James Young Simpson a Scottish physician introduced chloroform as an anesthetic agent during childbirth. Chloroform was first used on Queen Victoria, during her eighth delivery. |
| 1847 | Edward H. Barton at Vera Cruz, Mexico was the first to use sulfuric ether as the anesthetic agent for a leg amputation during wartime. |
| 1856 | John Snow, an English physician designed the chloroform inhaler, which delivered the anesthetic agent at optimum levels. He was the first to perform endotracheal anesthesia on a rabbit. |
| 1860 | Etienne Jules Marey a French physician discovered the sphygmographe. This device helped to record the pulse form on the forearm. |
| 1870 | Joseph T Clover an English surgeon improved the techniques of gas delivery and cautioned the physicians to monitor the vital signs. |
| 1875 | Claude Bernard a French physiologist Discovered the nerve muscle blocking action and the introduced the use of mixed anesthesia. |
| 1878 | Paul Bert the French physiologist along with the American surgeon Edmund W Andrews introduced nitrous oxide in Anesthesiology. |
| 1907 | Frederick J. Cotton and Walter M. Boothby invented an apparatus for the delivery of nitrous oxide, ether and oxygen. |
| 1908 | A.D Waller designs the chloroform balance, which determines the concentration of the vapor, received by the patient. |
| 1910 | Lincoln F. Sise invented the apparatus “introducer” for insertion of lumbar puncture needles. |
| 1936 | American society of Anesthetist was founded. |
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great information, but kindly include some advance use of Anaesthesia in different OT stages. thanks
Im surprised, to know the ancient methods of anaesthesia like forceful knock on head, snow anaesthesia etc.