|2700 BC||Shen Nung the second Chinese emperor who had tested the effects of 300 drugs on himself and has explained the narcotic properties of the Kemp plant.|
|1350 BC||The soporific and aphrodisiac properties of the mandrake were well known among the Egyptian Pharaohs.|
|77 AD||Dioscorides Pedanius a Greek physician in his fourth book of Materia Medica has gives details about the various substances that induces anesthesia. He coined the term anesthesia meaning lack of sensation in Greek.|
|1037||Avicenna an Iranian philosopher and physician said that the most powerful stupefacient is opium|
|1460||Heinrich von Pfolsprundt, a German military surgeon was the first to give an account of the soporific sponge (a recipe that suppresses sensation of pain) used in the treatment of gunshots.|
|1665||Sir Christopher Wren an English Architect with the help of Robert Boyle was the first to infuse opium and perform intravenousanesthesia in dogs.|
|1765||Matthew Turner an English chemist and surgeon was the first person to produce and sell ether. He recommended inhalation of sulfuric ether as a treatment for headaches.|
|1772||Joseph Priestley an English chemist discovered nitrous oxide.|
|1786||Cornelius Celsus described in detail about the preparation of the anodyne pills in the 46th edition of the Roman encyclopedia.|
|1817||Friedrich Serturner a German apothecary coined the term morphine and also elucidated the narcotic properties of opium.|
|1834||Jean Baptiste Dumas a French chemist unraveled the chemical structure and coined the term chloroform.|
|1847||Marie Jean Pierre Flourens and Francois-Achille Longet reported the effects and mode of action of ether on the central nervous system.|
|1847||Sir James Young Simpson a Scottish physician introduced chloroform as an anesthetic agent during childbirth. Chloroform was first used on Queen Victoria, during her eighth delivery.|
|1847||Edward H. Barton at Vera Cruz, Mexico was the first to use sulfuric ether as the anesthetic agent for a leg amputation during wartime.|
|1856||John Snow, an English physician designed the chloroform inhaler, which delivered the anesthetic agent at optimum levels. He was the first to perform endotracheal anesthesia on a rabbit.|
|1860||Etienne Jules Marey a French physician discovered the sphygmographe. This device helped to record the pulse form on the forearm.|
|1870||Joseph T Clover an English surgeon improved the techniques of gas delivery and cautioned the physicians to monitor the vital signs.|
|1875||Claude Bernard a French physiologist Discovered the nerve muscle blocking action and the introduced the use of mixed anesthesia.|
|1878||Paul Bert the French physiologist along with the American surgeon Edmund W Andrews introduced nitrous oxide in Anesthesiology.|
|1907||Frederick J. Cotton and Walter M. Boothby invented an apparatus for the delivery of nitrous oxide, ether and oxygen.|
|1908||A.D Waller designs the chloroform balance, which determines the concentration of the vapor, received by the patient.|
|1910||Lincoln F. Sise invented the apparatus “introducer” for insertion of lumbar puncture needles.|
|1936||American society of Anesthetist was founded.|
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