| YEAR | MILESTONES |
| 1847 | Sir James Young Simpson a Scottish physician introduced chloroform as an anesthetic agent during childbirth. Chloroform was first used on Queen Victoria, during her eighth delivery. |
| 1847 | Edward H. Barton at Vera Cruz, Mexico was the first to use sulfuric ether as the anesthetic agent for a leg amputation during wartime. |
| 1856 | John Snow, an English physician designed the chloroform inhaler, which delivered the anesthetic agent at optimum levels. He was the first to perform endotracheal anesthesia on a rabbit. |
| 1860 | Etienne Jules Marey a French physician discovered the sphygmographe. This device helped to record the pulse form on the forearm. |
| 1870 | Joseph T Clover an English surgeon improved the techniques of gas delivery and cautioned the physicians to monitor the vital signs. |
| 1875 | Claude Bernard a French physiologist Discovered the nerve muscle blocking action and the introduced the use of mixed anesthesia. |
| 1878 | Paul Bert the French physiologist along with the American surgeon Edmund W Andrews introduced nitrous oxide in Anesthesiology. |
| 1907 | Frederick J. Cotton and Walter M. Boothby invented an apparatus for the delivery of nitrous oxide, ether and oxygen. |
| 1908 | A.D Waller designs the chloroform balance, which determines the concentration of the vapor, received by the patient. |
| 1910 | Lincoln F. Sise invented the apparatus “introducer” for insertion of lumbar puncture needles. |
| 1936 | American society of Anesthetist was founded. |
