Ther Innov Regul Sci
Efficient Design of Integrated and Adaptively Interlinked Protocols for Early-Phase Drug Development Programs.
Coates S, Pohl O, Gotteland JP, Täubel J, Lorch U
Adaptive trial designs have the potential to address common challenges in drug development; they decrease timelines and costs of early drug developmen ...
Read More
Source: PubMed
Ther Innov Regul Sci
Determinants of Generic Drug Substitution in the United States.
Segal JB, Onasanya O, Daubresse M, Lee CY, Moechtar M, Pu X, Dutcher SK, Romanelli RJ
Some classes of drugs have lower than optimal uptake of generic products. We aimed to understand the determinants of generic drug substitution across ...
Read More
Source: PubMed
Cancer Chemother. Pharmacol. 2020 Feb 01
A Phase I dose-escalation, pharmacokinetics and food-effect study of oral donafenib in patients with advanced solid tumours.
Li X, Qiu M, Wang S, Zhu H, Feng B, Zheng L
This Phase I study evaluated the safety, tolerability, food effects, pharmacodynamics, and pharmacokinetics of donafenib in patients with advanced sol ...
Read More
Source: PubMed
Sci. Total Environ.
Enhancing nitrate and strontium concentration prediction in groundwater by using new data mining algorithm.
Bui DT, Khosravi K, Karimi M, Busico G, Khozani ZS, Nguyen H, Mastrocicco M, Tedesco D, Cuoco E, Kazakis N
Groundwater resources constitute the main source of clean fresh water for domestic use and it is essential for food production in the agricultural sec ...
Read More
Source: PubMed
Chemosphere
Mercury in fish marketed in the Amazon Triple Frontier and Health Risk Assessment.
Ferreira da Silva S, de Oliveira Lima M
Fish has great socioeconomic, cultural, and nutritional importance for Amazonian populations. Despite all health benefits, fish can accumulate great a ...
Read More
Source: PubMed
Ther Innov Regul Sci
Efficient Design of Integrated and Adaptively Interlinked Protocols for Early-Phase Drug Development Programs.
Coates S, Pohl O, Gotteland JP, Täubel J, Lorch U
Adaptive trial designs have the potential to address common challenges in drug development; they decrease timelines and costs of early drug developmen ...
Read More
Source: PubMed
Ther Innov Regul Sci
Determinants of Generic Drug Substitution in the United States.
Segal JB, Onasanya O, Daubresse M, Lee CY, Moechtar M, Pu X, Dutcher SK, Romanelli RJ
Some classes of drugs have lower than optimal uptake of generic products. We aimed to understand the determinants of generic drug substitution across ...
Read More
Source: PubMed
Cancer Chemother. Pharmacol. 2020 Feb 01
A Phase I dose-escalation, pharmacokinetics and food-effect study of oral donafenib in patients with advanced solid tumours.
Li X, Qiu M, Wang S, Zhu H, Feng B, Zheng L
This Phase I study evaluated the safety, tolerability, food effects, pharmacodynamics, and pharmacokinetics of donafenib in patients with advanced sol ...
Read More
Source: PubMed
Sci. Total Environ.
Enhancing nitrate and strontium concentration prediction in groundwater by using new data mining algorithm.
Bui DT, Khosravi K, Karimi M, Busico G, Khozani ZS, Nguyen H, Mastrocicco M, Tedesco D, Cuoco E, Kazakis N
Groundwater resources constitute the main source of clean fresh water for domestic use and it is essential for food production in the agricultural sec ...
Read More
Source: PubMed
Chemosphere
Mercury in fish marketed in the Amazon Triple Frontier and Health Risk Assessment.
Ferreira da Silva S, de Oliveira Lima M
Fish has great socioeconomic, cultural, and nutritional importance for Amazonian populations. Despite all health benefits, fish can accumulate great a ...
Read More
Source: PubMed
