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Indian Gooseberry for Cancer Prevention
Compelling preclinical studies with both in-vitro and in-vivo systems have shown that amla possesses anticancer, chemopreventive, cytoprotective, and radioprotective effects.
Various studies have shown amla extracts to inhibit growth of lung, liver, cervical, breast, ovarian and colorectal cancer cells.
Amla and some of its phytochemicals (gallic acid, pentagalloylglucose, ellagic acid, pyrogallol quercetin, and kaempferol) have found to be cytotoxic to neoplastic cells.
Several mechanisms are likely to be responsible for the cancer preventive effects of amla.
- Induction of apoptosis of neoplastic and preneoplastic cells
- Free radical scavenging, antioxidant, antimutagenic, anti-inflammatory activities
- Increase in glutathione S-transferase levels (an antioxidant enzyme)
- Decrease in excessive Phase 1 liver enzymes (which can convert chemicals into carcinogens)
- Decrease in lipid peroxidation
- Protection against DNA damage from various carcinogens
References:
- Chaudhuri ratan k. (2004) pcia conference, guangzhou, china
- Chen TS et al. Efficacy of epigallocatechin-3-gallate and amla (emblica officinalis) extract for the treatment of diabetic-uremic patients. med food. 2011 jul-aug; 14(7-8):718-23
- Nampoothiri SV et al. In vitro antioxidant and inhibitory potential of terminalia bellerica and emblica officinalis fruits against LDL oxidation and key enzymes linked to type 2 diabetes. Food chem toxicol. 2011 jan; 49(1):125-31.
- Sabu MC ; Kuttan R. Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. J ethnopharmacol. 2002 jul; 81(2):155-60.
- Akhtar MS et al. Effect of amla fruit (emblica officinalis gaertn.) on blood glucose and lipid profile of normal subjects and type 2 diabetic patients. Int j food sci nutr. 2011 sep; 62(6):609-16.
- Sampath kumar kp et al. Recent trends in potential traditional Indian herbs - Emblica officinalis and its medicinal importance. Journal of pharmacognosy and phytochemistry, vol. 1 no. 1 2012
- Shukla v et al. Evaluation of antioxidant profile and activity of amalaki (emblica officinalis), spirulina and wheat grass. Indian journal of clinical biochemistry, 2009 / 24 (1) 70-75
- Santhosh J et al. Hypolipidemic activity of phyllanthus emblica linn (amla) & trigonella foenum graecum (fenugreek) combination in hypercholesterolemic subjects – A Prospective, randomised, parallel, open-label, positive controlled study. Asian journal of biochemical and pharmaceutical research issue 1 (vol. 2) feb 2012
- Baliga MS ; Dsouza JJ. Amla(emblica officinalis gaertn), a wonder berry in the treatment and prevention of cancer.eur j cancer prev. 2011 may;20(3):225-39.
- Gopa. B et al. A comparative clinical study of hypolipidemic efficacy of Amla (Emblica officinalis) with 3-hydroxy-3-methylglutaryl-coenzyme-A reductase inhibitor simvastatin. Indian J Pharmacol. 2012 Mar-Apr; 44(2): 238–242.
Excellent information about this herb, I've been doing some research on alteratives herbs and this fruit will be very interesting to mention in my research.Thank you for info. Master in complementary and alternative science [ student]at ACHS in USA. Ricardo jimenez