Indian Gooseberry for Cancer Prevention
Compelling preclinical studies with both in-vitro and in-vivo systems have shown that amla possesses anticancer, chemopreventive, cytoprotective, and radioprotective effects.
Various studies have shown amla extracts to inhibit growth of lung, liver, cervical, breast, ovarian and colorectal cancer cells.
Amla and some of its phytochemicals (gallic acid, pentagalloylglucose, ellagic acid, pyrogallol quercetin, and kaempferol) have found to be cytotoxic to neoplastic cells.
Several mechanisms are likely to be responsible for the cancer preventive effects of amla.
- Induction of apoptosis of neoplastic and preneoplastic cells
- Free radical scavenging, antioxidant, antimutagenic, anti-inflammatory activities
- Increase in glutathione S-transferase levels (an antioxidant enzyme)
- Decrease in excessive Phase 1 liver enzymes (which can convert chemicals into carcinogens)
- Decrease in lipid peroxidation
- Protection against DNA damage from various carcinogens
- Chaudhuri ratan k. (2004) pcia conference, guangzhou, china
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- Santhosh J et al. Hypolipidemic activity of phyllanthus emblica linn (amla) & trigonella foenum graecum (fenugreek) combination in hypercholesterolemic subjects – A Prospective, randomised, parallel, open-label, positive controlled study. Asian journal of biochemical and pharmaceutical research issue 1 (vol. 2) feb 2012
- Baliga MS ; Dsouza JJ. Amla(emblica officinalis gaertn), a wonder berry in the treatment and prevention of cancer.eur j cancer prev. 2011 may;20(3):225-39.
- Gopa. B et al. A comparative clinical study of hypolipidemic efficacy of Amla (Emblica officinalis) with 3-hydroxy-3-methylglutaryl-coenzyme-A reductase inhibitor simvastatin. Indian J Pharmacol. 2012 Mar-Apr; 44(2): 238–242.