Anal Bioanal Chem 2020 Feb 01
Fully automated chip-based nanoelectrospray ionization-mass spectrometry as an effective tool for rapid and high-throughput screening of 5a-reductase inhibitors.
Zheng R, Li L, Deng X, Tian M, Wang Z, Yang L
The 5a-reductase converts testosterone to dihydrotestosterone (DHT), and excess DHT could cause androgen-related diseases such as androgenetic alopeci ...
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Source: PubMed
J. Am. Acad. Dermatol. 2020 Jan 29
Bidirectional association between alopecia areata and major depressive disorder among probands and unaffected siblings: A nationwide population-based study.
Dai YX, Tai YH, Chen CC, Chang YT, Chen TJ, Chen MH
Alopecia areata (AA) has long been associated with major depressive disorder (MDD). However, most evidence to date has derived from cross-sectional or ...
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Source: PubMed
Gene Ther. 2020 Jan 31
Adeno-associated virus vector enables safe and efficient Cas9 activation in neonatal and adult Cas9 knockin murine cochleae.
Kang W, Zhao X, Sun Z, Dong T, Jin C, Tong L, Zhu W, Tao Y, Wu H
Adeno-associated virus (AAV)-mediated gene delivery systems have been shown to be effective tools for gene manipulation in the inner ear. For example, ...
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Source: PubMed
Am. J. Med. Genet. A 2020 Jan 31
Genetic evaluation including exome sequencing of two patients with Gomez-Lopez-Hernandez syndrome: Case reports and review of the literature.
Lindsay F, Anderson I, Wentzensen IM, Suhrbier D, Stevens CA
Rhombencephalosynapsis (RES) is a rare congenital anomaly of the hindbrain characterized by fusion of the cerebellar hemispheres, cerebellar peduncles ...
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Source: PubMed
Acta Otolaryngol. 2020 Jan 31
Transient-evoked otoacoustic emission signals predicting outcomes of acute sensorineural hearing loss in patients with Ménière's disease.
Liu YW, Kao SL, Wu HT, Liu TC, Fang TY, Wang PC
Background: Fluctuating hearing loss is characteristic of Ménière's disease (MD) during acute episodes. However, no reliable audiometric hallmarks are ...
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Source: PubMed
