What is Graviola Tree?Graviola (Annona muricata) is a rainforest tree, classified under the pineapple family Annonaceae. Also known as soursop or raintree or Brazilian paw paw, it is found in the belt extending from Central America to South America, including parts of Brazil.
Graviola has gained much importance because of acetogenins, a group of potential anti-cancer agents, found in this plant.
Graviola has a number of uses, especially therapeutic. Leaves, seeds, bark, fruits and roots are the traditionally used parts of this tree. Listed are some of the traditional and herbal uses of this tree.
1. Leaves are used for headaches and insomnia. The leaves also contain antioxidants known to fight inflammation.
2. Cooked leaves, applied topically, fight rheumatism and abscesses. In certain regions of Brazil, the oil of the leaves and unripe fruit is mixed with olive oil and used externally for neuralgia, rheumatism, and arthritis pain.
3. The fruit and fruit juice are used-
- as deworming and antiparasitic agents
- as an astringent for diarrhea and dysentery
- to cool fevers, and
- to increase mother's milk after childbirth
4. The seeds are crushed and used against internal and external parasites, head lice, and worms. However, it is important to note that seeds and roots contain certain toxins that could cause atypical Parkinson’s disease, so this herbal remedy is best avoided.
5. Tea made from Graviola leaves has long been used in the Amazon region to treat liver and stomach disorders.
6. A tea made from the bark, leaves, and roots are used-
Graviola is best known for its anti-cancer properties. Researchers are very enthusiastic about Graviola being an alternative medicine to be used as supportive therapy for cancers, such as breast cancer, prostate cancer, liver cancer, lung cancer, pancreatic cancer, and lymphoma. It is one of the most studied properties of the tree and so far it has shown positive results. However, always consult your doctor before using Graviola for any therapy, as most studies regarding the health benefits of Graviola have been conducted only on laboratory animals and have not been confirmed in humans.
Pancreatic cancer: An increased metabolic activity and glucose concentration in the tumor cell has been linked to aggressive pancreatic cancer. One study published in the journal Cancer Letters showed that Graviola extract containing acetogenins acted in a way to decrease ATP production, thus, leading to death of cancer cells. Incidentally, the researchers found that it does not affect the healthy cells.
Lung cancer- Adriamycin is sometimes used as chemotherapy drugs for cancers including lung cancer and blood cancers. A Japanese study done on lab animals found that annonacin (acetogenin) could inhibit the growth of cancer cells in the lungs as much as Adriamycin, if not better. However, R. Webster Kehr, at Independent Cancer Research Foundation, warns that Graviola can be especially dangerous for lung cancer patients and brain cancer patients where a clustered amount of cancer dead cells (lysing) can be very dangerous.
Analgesic and anti-inflammatory properties- A study published in the International Journal of Molecular Sciences on experimental animals supported these traditional uses for analgesic and anti-inflammatory activities, suggesting a potential for therapeutic purposes. However, the researchers suggested further studies to be conducted to ensure its safe usage.
Diabetes- Graviola has been found to be beneficial in cases of diabetes. A Nigerian study revealed that leaf extract of Graviola significantly reduced blood glucose concentration in experimental animals, possibly by enhancing the effects of insulin and adrenalin. No human trials have yet been done, therefore its use for this purpose cannot be recommended.
Side Effects of Graviola
Although seeds and roots of graviola contain acetogenins that help in cancer therapy, they are best avoided because other chemicals present in these parts have shown neurotoxic effects similar that of atypical Parkinson’s disease.
There is no evidence that taking Graviola in pregnancy and lactation is safe. Consult your doctor regarding the use of this alternative medicine.
|Calcium, Ca||14 mg||1.4 %|
|Copper, Cu||0.09 mg||4.3 %|
|Iron, Fe||0.6 mg||3.33 %|
|Magnesium, Mg||21 mg||5.25 %|
|Phosphorus, P||27 mg||2.7 %|
|Potassium, K||278 mg||7.94 %|
|Selenium, Se||0.6 mcg||0.86 %|
|Sodium, Na||14 mg||0.58 %|
|Zinc, Zn||0.1 mg||0.67 %|
|Vitamin A||2 IU||0.04 %|
|Vitamin C||20.6 mg||34.33 %|
|Vitamin B6||0.06 mg||2.95 %|
|Vitamin E||0.08 mg||0.27 %|
|Vitamin K||0.4 mcg||0.5 %|
|Riboflavin||0.05 mg||2.94 %|
|Thiamin||0.07 mg||4.67 %|
|Folate, DFE||14 mcg||3.5 %|
|Niacin||0.9 mg||4.5 %|
|Fiber||3.3 g||13.2 %|
|Cholesterol||0 mg||0 %|
|Carotene, alpha||0 mcg|
|Carotene, beta||1 mcg|
|View all +|
Latest Publications and Research on Graviola, Natural Cancer KillerStructural Characterization of Cellulose Obtained from Extraction Wastes of Graviola (Annona muricata) Leaf. - Published by PubMed
Annonacin promotes selective cancer cell death via NKA-dependent and SERCA-dependent pathways. - Published by PubMed
Graviola (Annona muricata) Exerts Anti-Proliferative, Anti-Clonogenic and Pro-Apoptotic Effects in Human Non-Melanoma Skin Cancer UW-BCC1 and A431 Cells In Vitro: Involvement of Hedgehog Signaling. - Published by PubMed