Protease Inhibitors (PIs)

PIs disable protease, a protein that HIV needs to make more copies of itself.

Long term side effects of protease inhibitors: Change in blood sugar levels

Increase in blood fat levels
Deposition of fat in the abdomen and on the back of the shoulders.

Drug	Dosage	Side Effects
Invirase	Five 200 mg capsules of Invirase + one 100 mg of Norvir, twice a day.	Nausea, diarrhea, stomach discomfort, insominia, headache, increased liver enzyme levels. Invirase and Norvir should be taken with food, or within 2 hours after a meal.
Fortovase	Six 200 mg capsules, three times a day plus one 100 mg Norvir, twice daily.	Nausea, diarrhea, stomach discomfort, insominia, headache, increased liver enzyme levels.
Norvir/Ritonavir	Six 100mg capsules, twice a day.	Nausea, diarrhea, stomach discomfort, insominia, headache, increased liver enzyme levels, loss of appetite, oral tingling and numbness. Capsules should be stored in refrigerator, Used at lower doses to enhance other protease inhibitors.
Crixivan / Indinavir	Two 400 mg capsules, every 8 hours.	Kidney stones, nausea, vomiting, diarrhea, stomach discomfort, headache, insomnia, rash, back pain. Take on an empty stomach, drink atleast 8 glasses of water daily to prevent kidney stone formation.
Viracept / Nelfinavir	Five 250 mg tablets, twice a day.	Diarrhea, nausea, stomach discomfort, gas, rash, increased liver enzyme levels. Drug to be taken with meal.
Agenerase / Amprenavir	Eight 150 mg capsules, twice a day.	Rash, diarrhea, nausea, vomiting, oral tingling and numbness. Drug can be taken with or without food, but avoid taking high-fat meals.
Kaletra / Lopinavir + Ritonavir	Three capsules, twice a day.	Diarrhea, nausea, feeling tired, headache, Pancreatitis.
Reyataz / Atazanavir	Two 200mg capsules, once a day.	Increased levels of bilirubin, headaches, pain in the arms and legs, nausea, diarrhea, rash. Should be taken with a light meal.
Lexiva / Fosamprenavir	Two 700 mg tablets, twice a day.	Rash, diarrhea, nausea, vomiting.

Published on Sep 06, 2014
Last Updated on Aug 26, 2020

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