Protease Inhibitors (PIs)

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Dr. Reeja Tharu
Medically Reviewed by The Medindia Medical Review Team  on Sep 26, 2016
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Protease Inhibitors (PIs)

PIs disable protease, a protein that HIV needs to make more copies of itself.

Long term side effects of protease inhibitors: Change in blood sugar levels

  • Increase in blood fat levels
  • Deposition of fat in the abdomen and on the back of the shoulders.

DrugDosageSide Effects
InviraseFive 200 mg capsules of Invirase + one 100 mg of Norvir, twice a day.Nausea, diarrhea, stomach discomfort, insominia, headache, increased liver enzyme levels. Invirase and Norvir should be taken with food, or within 2 hours after a meal.
FortovaseSix 200 mg capsules, three times a day plus one 100 mg Norvir, twice daily.Nausea, diarrhea, stomach discomfort, insominia, headache, increased liver enzyme levels.
Norvir/RitonavirSix 100mg capsules, twice a day.Nausea, diarrhea, stomach discomfort, insominia, headache, increased liver enzyme levels, loss of appetite, oral tingling and numbness. Capsules should be stored in refrigerator, Used at lower doses to enhance other protease inhibitors.
Crixivan / IndinavirTwo 400 mg capsules, every 8 hours.Kidney stones, nausea, vomiting, diarrhea, stomach discomfort, headache, insomnia, rash, back pain. Take on an empty stomach, drink atleast 8 glasses of water daily to prevent kidney stone formation.
Viracept / NelfinavirFive 250 mg tablets, twice a day.Diarrhea, nausea, stomach discomfort, gas, rash, increased liver enzyme levels. Drug to be taken with meal.
Agenerase / AmprenavirEight 150 mg capsules, twice a day.Rash, diarrhea, nausea, vomiting, oral tingling and numbness. Drug can be taken with or without food, but avoid taking high-fat meals.
Kaletra / Lopinavir + RitonavirThree capsules, twice a day.Diarrhea, nausea, feeling tired, headache, Pancreatitis.
Reyataz / AtazanavirTwo 200mg capsules, once a day.Increased levels of bilirubin, headaches, pain in the arms and legs, nausea, diarrhea, rash. Should be taken with a light meal.
Lexiva / FosamprenavirTwo 700 mg tablets, twice a day.Rash, diarrhea, nausea, vomiting.

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am 19 years old i hv been wid hiv since i wz kid but i live wid out ant medicion till now but i start to get sick so fast am univresty student so wht do u suggest me?

start medication. HIV virus didnt dominated you for long period. it was affecting your immune system now its effecting your health. Start the therapy as soon as possible

I am from Ethiopia aged 41. I didn't start the treatment and knew that I'm affected by the virus before 1 year am the man work serious place in gov't instituition. Now I want to start treatment immediately. I NEED SERIOUS help and advise from you. I do not want to die.

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