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Symptoms and Signs of Brain Metastasis

Last Updated on Nov 27, 2018
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What are the Symptoms and Signs of Brain Metastasis?

Some of the clinical features of brain metastases are:

  • Convulsions or seizures
  • Headaches, which occur during sleep and get progressively worse
  • Cognitive deficiencies, such as memory loss, lethargy, lack of attention, weakness, and disinterest in activities
  • Weakness, based on the area of the brain in which the tumor develops. This affects bodily functions on the affected side of the body
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  • Loss of sensation
  • Abnormalities in gait
  • Speech and vision abnormalities
  • Aphasia or trouble finding the right word
  • Neurological deficits, including increased intracranial pressure, displaced or destroyed brain tissue, and swelling that affects adjacent regions.
Symptoms and Signs of Brain Metastasis

The region in the brain where the tumor grows, affects the associated side of the body with loss of sensory capabilities or disturbance in gait. More than half of those affected with brain metastasis, display cognitive difficulties and weakness.

References:

  1. Mukherjee S. The Emperor of all Maladies: A Biography of Cancer. London: Fourth Estate, 2011.
  2. Vachani C. All about brain metastases - OncoLink - (https://www.oncolink.org/cancers/brain-tumors/brain-metastasis/all-about-brain-metastases)
  3. Gould J. Breaking down the epidemiology of brain cancer. Nature. 2018; 561: S40-S41. - (https://www.nature.com/articles/d41586-018-06704-7)
  4. Eichler AF, Loeffler JS. Multidisciplinary management of brain metastases. Oncologist. 2007;12(7): 884-98. - (http://theoncologist.alphamedpress.org/content/12/7/884.full)
  5. Hardesty DA, Nakaji P. The current and future treatment of brain metastases. Front Surg. 2016; 3: 30. (DOI:10.3389/fsurg.2016.00030). PMID: 27252942. - (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879329/)
  6. Newton HB. Neurologic complications of systemic cancer. Am Fam Physician. 1999; 59(4): 878-86. - (https://www.aafp.org/afp/1999/0215/p878.html)
  7. Nivolumab and ipilimumab effective against melanoma that has spread to the brain - National Cancer Institute, National Institutes of Health (NIH), USA - (https://www.cancer.gov/news-events/cancer-currents-blog/2018/melanoma-brain-metastases-nivolumab-ipilimumab)
  8. Shipp S. Structure and function of the cerebral cortex. Curr Biol. 2007; 17(12): PR443-449. - (https://www.cell.com/current-biology/fulltext/S0960-9822(07)01148-7#secsection0015)

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