About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

PUVA Therapy / Photochemotherapy

Last Updated on Dec 15, 2017
Font : A-A+

What is PUVA Therapy?

PUVA is a combination treatment which consists of psoralen taken orally or applied to the skin followed by exposure of the skin to long wave ultraviolet A (UVA) radiation. It is used for the treatment of certain types of skin diseases.

Advertisement

Psoralen is a drug that makes the skin temporarily sensitive to UVA. The ultraviolet light is emitted by special fluorescent light tubes. The treatment is given in a hospital set up, and cannot be administered at home. The treatment may require a variable number of sittings, depending on the condition being treated and its severity.

What is PUVA Therapy Used for?

PUVA therapy is used for the treatment of a number of skin diseases which include psoriasis, eczema, atopic dermatitis, cutaneous T-cell lymphoma, vitiligo, graft-versus-host disease, and polymorphic light eruptions. However, due to its disadvantages and side effects, it is recommended only when other treatments fail.

PUVA Therapy Uses

How is PUVA Therapy Administered?

PUVA can be used for both, the whole body and local (hand and foot) treatments. First, the psoralen is administered orally or is applied to the required part of the skin. In some cases, the patient soaks in a bath that contains psoralen. After approximately 2 hours after the oral intake of the psoralen when the drug has reached the skin, the UVA treatment is administered.

In case of whole body PUVA therapy, the patient stands undressed in a specially designed cabinet containing fluorescent light tubes. When a specific area is treated, only the affected hand or leg is exposed to the radiation. Sensitive body parts such as the face, eyes, breast, and genitals are covered to protect them from the potential carcinogenic effect of the UV radiation.

Advertisement

How Safe is PUVA Therapy?

PUVA is recommended only when other treatments fail to benefit the patient because of its side effects. However, acute treatments given by trained professionals, with accurate dose, duration, and schedule are usually safe and have been beneficial to patients suffering from chronic skin diseases. Minor side effects such as burning, itching, or redness can be managed with topical treatments.

Though it is not clear whether PUVA therapy affects the developing baby during pregnancy, couples are advised to avoid planning a family while on PUVA therapy or stop the therapy immediately if pregnancy is confirmed.

What are the Side Effects of PUVA Therapy?

The side effects of PUVA therapy include the following:

  • Skin: Several skin reactions can occur during the treatment. These include:
    • Phototoxic erythema, a sunburn-type reaction, which occurs more commonly in fair-skinned patients and 48 to 72 hours after the first two or three treatments. Moisturizers and painkillers are used to reduce the discomfort. The patient is advised to avoid exposure to direct sunlight after taking the psoralen, as it can cause sunburns.
    • Dryness of the skin resulting in itching. It is treated with a moisturiser and sometimes an antihistamine
    • Tanning of the skin that may last several months
    • Premature aging changes such as wrinkles, freckles and lentigines. Long-term treatment can increase the chances of skin cancer especially in Caucasians
  • Nausea: Nausea if present, can be treated with medications for vomiting.
  • Eye damage: Eye damage can be in the form of keratitis (damage to the cornea) or an increased risk of cataract. The eyes should be protected during the treatment as well as until bedtime at night on the day of the treatment.
Side Effects of PUVA Therapy

Health Tips for those Undergoing PUVA Therapy

  • Do not apply any ointments or cosmetics (especially perfumes and coal tar products) on the skin except as directed by your doctor. You may need to apply a moisturizer prescribed by a doctor. Inform your doctor if you need to take any other medication.
Advertisement
  • Always take the psoralen capsules at exactly the same interval before the UVA exposure.
  • Alcohol consumption should be avoided during the treatment.
  • Avoid sun exposure on the treatment and non-treatment days. Cover your body as much as possible when exposed to sunlight. Apply sunscreen to all uncovered parts.
  • Follow up with your skin specialist regularly even if you feel fine.
Health Tips for PUVA Therapy

References:

  1. PUVA (Photochemotherapy) - (https://www.dermnetnz.org/topics/puva-photochemotherapy/)
  2. PUVA Treatment - (http://www.ouh.nhs.uk/patient-guide/leaflets/files/120719puva.pdf)
  3. Cutaneous Carcinogenic Risk of Phototherapy: An Updated Comprehensive Review - (https://www.psoriasis.org/content/cutaneous-carcinogenic-risk-phototherapy-updated-comprehensive-review)

Latest Publications and Research on PUVA Therapy

Citations   close

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Dr. Rachita Narsaria. (2017, December 15). PUVA Therapy | Photochemotherapy - Side Effects & Health Tips. Medindia. Retrieved on May 28, 2022 from https://www.medindia.net/patientinfo/puva-therapy.htm.

  • MLA

    Dr. Rachita Narsaria. "PUVA Therapy | Photochemotherapy - Side Effects & Health Tips". Medindia. May 28, 2022. <https://www.medindia.net/patientinfo/puva-therapy.htm>.

  • Chicago

    Dr. Rachita Narsaria. "PUVA Therapy | Photochemotherapy - Side Effects & Health Tips". Medindia. https://www.medindia.net/patientinfo/puva-therapy.htm. (accessed May 28, 2022).

  • Harvard

    Dr. Rachita Narsaria. 2021. PUVA Therapy | Photochemotherapy - Side Effects & Health Tips. Medindia, viewed May 28, 2022, https://www.medindia.net/patientinfo/puva-therapy.htm.


Do you wish to consult a Dermatologist for your problem? Ask your question

Dr. Sarita Tippannawar
Dr. Sarita Tippannawar
MBBS, DDVL
18 years experience
Teleconsult Now View Profile
Dr. Rashmi Naldeega
Dr. Rashmi Naldeega
MBBS, DDVL
5 years experience
Teleconsult Now View Profile
View All

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.

Advertisement
Health Topics A - Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z



    Advertisement
    What's New on Medindia
    World Multiple Sclerosis (MS) Day 2022 —
    Monkeypox Outbreak: What it is, How Does it Spread & the Prevention
    Seasonal Allergy Medications
    View all
    Advertisement

    Medindia Newsletters Subscribe to our Free Newsletters!
    Terms & Conditions and Privacy Policy.

    Most Popular on Medindia

    Blood - Sugar Chart Sinopril (2mg) (Lacidipine) Vent Forte (Theophylline) Indian Medical Journals Calculate Ideal Weight for Infants Selfie Addiction Calculator Daily Calorie Requirements Blood Pressure Calculator Nutam (400mg) (Piracetam) Diaphragmatic Hernia

    Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

    © All Rights Reserved 1997 - 2022

    This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use