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Lynch Syndrome

Latest Publications and Research on Lynch Syndrome


J. Am. Coll. Surg.   2020 Jan 30   

Risk of Metachronous Colorectal Neoplasm After a Segmental Colectomy in Lynch Syndrome Patients According to Mismatch Repair Gene Status.

Quezada-Diaz FF, Hameed I, von Mueffling A, Salo-Mullen EE, Catalano JD, Smith JJ, Weiser MR, Garcia-Aguilar J, Stadler ZK, Guillem JG

Because of increased risk of metachronous colorectal cancer (CRC), all Lynch Syndrome (LS) patients are offered a total colectomy. However, since meta ... Read More

Source: PubMed
Fam. Cancer   2020 Jan 30   

Prevalence of CNV-neutral structural genomic rearrangements in MLH1, MSH2, and PMS2 not detectable in routine NGS diagnostics.

Morak M, Steinke-Lange V, Massdorf T, Benet-Pages A, Locher M, Laner A, Kayser K, Aretz S, Holinski-Feder E

Routine diagnostics for colorectal cancer patients suspected of having Lynch-Syndrome (LS) currently uses Next-Generation-Sequencing (NGS) of targeted ... Read More

Source: PubMed
Front Immunol      

Distinct Immunological Landscapes Characterize Inherited and Sporadic Mismatch Repair Deficient Endometrial Cancer.

Ramchander NC, Ryan NAJ, Walker TDJ, Harries L, Bolton J, Bosse T, Evans DG, Crosbie EJ

Around 30% of endometrial cancers (EC) are mismatch repair (MMR) deficient, mostly as a consequence of mutations acquired during tumorigenesis, but a ... Read More

Source: PubMed
Fam. Cancer   2020 Jan 29   

Factors associated with decision-making on prophylactic hysterectomy and attitudes towards gynecological surveillance among women with Lynch syndrome (LS): a descriptive study.

Kalamo MH, Mäenpää JU, Seppälä TT, Mecklin JP, Huhtala H, Sorvettula K, Pylvänäinen K, Staff S

To prevent endometrial carcinoma in Lynch syndrome (LS), regular gynecological surveillance visits and prophylactic surgery are recommended. Previous ... Read More

Source: PubMed
Fam. Cancer   2020 Jan 29   

Detection of DNA mismatch repair deficient crypts in random colonoscopic biopsies identifies Lynch syndrome patients.

Brand RE, Dudley B, Karloski E, Das R, Fuhrer K, Pai RK, Pai RK

The hallmark of Lynch syndrome (LS)-associated neoplasia is DNA mismatch repair protein (MMR) deficiency. Recent studies have demonstrated that histol ... Read More

Source: PubMed
J. Am. Coll. Surg.   2020 Jan 30   

Risk of Metachronous Colorectal Neoplasm After a Segmental Colectomy in Lynch Syndrome Patients According to Mismatch Repair Gene Status.

Quezada-Diaz FF, Hameed I, von Mueffling A, Salo-Mullen EE, Catalano JD, Smith JJ, Weiser MR, Garcia-Aguilar J, Stadler ZK, Guillem JG

Because of increased risk of metachronous colorectal cancer (CRC), all Lynch Syndrome (LS) patients are offered a total colectomy. However, since meta ... Read More

Source: PubMed
Fam. Cancer   2020 Jan 30   

Prevalence of CNV-neutral structural genomic rearrangements in MLH1, MSH2, and PMS2 not detectable in routine NGS diagnostics.

Morak M, Steinke-Lange V, Massdorf T, Benet-Pages A, Locher M, Laner A, Kayser K, Aretz S, Holinski-Feder E

Routine diagnostics for colorectal cancer patients suspected of having Lynch-Syndrome (LS) currently uses Next-Generation-Sequencing (NGS) of targeted ... Read More

Source: PubMed
Front Immunol      

Distinct Immunological Landscapes Characterize Inherited and Sporadic Mismatch Repair Deficient Endometrial Cancer.

Ramchander NC, Ryan NAJ, Walker TDJ, Harries L, Bolton J, Bosse T, Evans DG, Crosbie EJ

Around 30% of endometrial cancers (EC) are mismatch repair (MMR) deficient, mostly as a consequence of mutations acquired during tumorigenesis, but a ... Read More

Source: PubMed
Fam. Cancer   2020 Jan 29   

Factors associated with decision-making on prophylactic hysterectomy and attitudes towards gynecological surveillance among women with Lynch syndrome (LS): a descriptive study.

Kalamo MH, Mäenpää JU, Seppälä TT, Mecklin JP, Huhtala H, Sorvettula K, Pylvänäinen K, Staff S

To prevent endometrial carcinoma in Lynch syndrome (LS), regular gynecological surveillance visits and prophylactic surgery are recommended. Previous ... Read More

Source: PubMed
Fam. Cancer   2020 Jan 29   

Detection of DNA mismatch repair deficient crypts in random colonoscopic biopsies identifies Lynch syndrome patients.

Brand RE, Dudley B, Karloski E, Das R, Fuhrer K, Pai RK, Pai RK

The hallmark of Lynch syndrome (LS)-associated neoplasia is DNA mismatch repair protein (MMR) deficiency. Recent studies have demonstrated that histol ... Read More

Source: PubMed
J. Am. Coll. Surg.   2020 Jan 30   

Risk of Metachronous Colorectal Neoplasm After a Segmental Colectomy in Lynch Syndrome Patients According to Mismatch Repair Gene Status.

Quezada-Diaz FF, Hameed I, von Mueffling A, Salo-Mullen EE, Catalano JD, Smith JJ, Weiser MR, Garcia-Aguilar J, Stadler ZK, Guillem JG

Because of increased risk of metachronous colorectal cancer (CRC), all Lynch Syndrome (LS) patients are offered a total colectomy. However, since meta ... Read More

Source: PubMed
Fam. Cancer   2020 Jan 30   

Prevalence of CNV-neutral structural genomic rearrangements in MLH1, MSH2, and PMS2 not detectable in routine NGS diagnostics.

Morak M, Steinke-Lange V, Massdorf T, Benet-Pages A, Locher M, Laner A, Kayser K, Aretz S, Holinski-Feder E

Routine diagnostics for colorectal cancer patients suspected of having Lynch-Syndrome (LS) currently uses Next-Generation-Sequencing (NGS) of targeted ... Read More

Source: PubMed
Front Immunol      

Distinct Immunological Landscapes Characterize Inherited and Sporadic Mismatch Repair Deficient Endometrial Cancer.

Ramchander NC, Ryan NAJ, Walker TDJ, Harries L, Bolton J, Bosse T, Evans DG, Crosbie EJ

Around 30% of endometrial cancers (EC) are mismatch repair (MMR) deficient, mostly as a consequence of mutations acquired during tumorigenesis, but a ... Read More

Source: PubMed
Fam. Cancer   2020 Jan 29   

Factors associated with decision-making on prophylactic hysterectomy and attitudes towards gynecological surveillance among women with Lynch syndrome (LS): a descriptive study.

Kalamo MH, Mäenpää JU, Seppälä TT, Mecklin JP, Huhtala H, Sorvettula K, Pylvänäinen K, Staff S

To prevent endometrial carcinoma in Lynch syndrome (LS), regular gynecological surveillance visits and prophylactic surgery are recommended. Previous ... Read More

Source: PubMed
Fam. Cancer   2020 Jan 29   

Detection of DNA mismatch repair deficient crypts in random colonoscopic biopsies identifies Lynch syndrome patients.

Brand RE, Dudley B, Karloski E, Das R, Fuhrer K, Pai RK, Pai RK

The hallmark of Lynch syndrome (LS)-associated neoplasia is DNA mismatch repair protein (MMR) deficiency. Recent studies have demonstrated that histol ... Read More

Source: PubMed
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