Erythroblastosis Fetalis - Frequently Asked Questions

4. What is isoimmunization?

It is the production by an individual of antibodies against constituents of the tissues of another individual of the same species. In the context of erythroblastosis fetalis, this occurs when fetal RBCs, which possess an antigen that the mother lacks, are transferred transplacentally, and elicit antibody induction in the mother’s body. Subsequently, the antibodies return to the fetus by the same route, resulting in RBC lysis.

5. What should I do to ensure that my baby is out of danger?

You should visit your neonatologist regularly for at least 3 to 4 months to monitor for signs of anemia. If required, further blood transfusions may be given. With proper care, your baby should have no further complications.

6. Why autoimmune hemolytic anemia is also called Coombs disease?

Autoimmune hemolytic anemia is a rare disease in which antibodies are made against a person’s own RBCs. It is also known as Coombs disease because two blood tests can check for antibodies that attack RBCs. These are the direct Coombs test and the indirect Coombs test.