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Diagnosis and Treatment of Amyloidosis

Last Updated on Mar 08, 2019
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How do you Diagnose Amyloidosis?

  • Blood and Urine Tests: These are tested for abnormal proteins and to rule out presence of other diseases which may cause amyloidosis
  • Bone Marrow Biopsy: A bone marrow tissue sample may be obtained by biopsy for histochemical and microscopic studies to identify abnormal amyloid proteins
  • Tissue Biopsy: This is essential to confirm diagnosis of amyloidosis. A tissue sample is obtained by biopsy and examined by immunohistochemistry (IHC) and microscopy for the presence of any amyloid fibrils
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How can you Treat and Manage Amyloidosis?

Currently, there is no cure for amyloidosis. Treatment aims to reduce the symptoms and prevent further deposition of amyloid proteins in the body tissues. Management of amyloidosis depends on the type of amyloidosis and the organs affected.

  • Medications: These are used for treating underlying diseases such as autoimmune diseases, chronic infections or inflammatory diseases such as rheumatoid arthritis, tuberculosis and ulcerative colitis. Painkillers may be used for managing pain and antiarrhythmic drugs may be used to stabilize the heartbeat
Medication, Chemotherapy or a Stem-Cell Transplant are Few Treatment Options for Amyloidosis

References:

  1. Light-Chain (AL) Amyloidosis: Diagnosis and Treatment - (https://cjasn.asnjournals.org/content/1/6/1331)
  2. Amyloidosis - (https://rarediseases.org/rare-diseases/amyloidosis/)
  3. About Amyloidosis - (https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/amyloidosis)
  4. Amyloidosis-Associated Kidney Disease - (https://jasn.asnjournals.org/content/17/12/3458)
  5. Amyloidosis & Kidney Disease - (https://www.niddk.nih.gov/health-information/kidney-disease/amyloidosis)
  6. AL Amyloidosis - (http://amyloidosis.org/facts/al/#diagnosis)

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