Cold intolerance results in numbness, changes in color of the skin, weakness, and tingling sensation. Between 38% and 83% of patients who undergo trauma in their hands experience cold intolerance. Severe cold intolerance is experienced during amputations or complex trauma. Bone, nerve, and tendon injuries may also result in symptoms of cold sensitivity.
What are the Causes of Cold Intolerance?Cold intolerance is a symptom of any of the underlying medical conditions mentioned below:
- Improper functioning of the hypothalamus – this part of the brain regulates body temperature
- Trauma, injury or surgery to the upper limbs (e.g. amputation, digital replantation, injury to the tendon)
- Body pain and discomfort (fibromyalgia)
- Blood flow complications (e.g. Raynaud's syndrome)
- Anorexia nervosa - an eating disorder
- Hypothyroidism (deficiency in thyroid hormones)
- Chemotherapy drug-induced nerve injuries (e.g. oxaliplatin, bortezomib, thalidomide)
- Nerve injuries (e.g. multiple sclerosis)
- Enzyme treatment
- Defects in functioning of body proteins
- Altered blood supply
What are the Signs and Symptoms of Cold Intolerance?As one can guess, the principal symptom of cold intolerance is the inability to handle cold. Some of the other symptoms are:
- A tingling sensation
- Stiffness or weakness in the fingers and hand when exposed to cold
- Change in skin color
- Normal function of injured or reconstructed limb is affected
How do you Diagnose Cold Intolerance?Your physician will need to know your medical history to understand what may be causing this intolerance to cold.
The Cold Intolerance Symptom Severity (CISS) questionnaire is used as a standard to assess the symptoms of cold intolerance and its effect on your work and daily life. However, CISS can only give information for the symptoms you are experiencing due to cold intolerance. It does not give an idea of what may have caused the cold intolerance to develop.
- Describe your general health.
- Describe the symptoms you are experiencing.
- When did you begin experiencing these symptoms?
- What is your weight and height?
- Describe your diet.
- Did you ever have problems with cold earlier?
- Do you feel cold when others do not?
- Do you find your symptoms are becoming worse?
How do you Treat Cold Intolerance?There is no effective treatment for cold intolerance since it is not clear how the symptom arises. Is it related to nerve injuries or to defects in the blood circulation? The symptom of cold intolerance may arise due to an underlying condition or injury or treatment. Hence, therapies, such as the following are recommended:
- Hand therapy
- Behavior therapy -
- Make sure you sit in warm surroundings. Hence, a warm office or house is a good way to avoid feeling cold.
- Move around to increase blood circulation and reduce any stiffness in muscles due to the cold.
- Wear warm clothing (e.g. sweaters, thermal gloves, thermal socks) if you are working in cold places (e.g. in butcher shops).
- Try and get the warmth of the sun by sitting outside.
In severe cases of cold intolerance, vasodilator-type drugs are prescribed as treatment.
Latest Publications and Research on Cold IntoleranceMembrane Fluidity Is Regulated Cell Non-autonomously by Caenorhabditiselegans PAQR-2 and Its Mammalian Homolog AdipoR2. - Published by PubMed
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