Melanie L. Wyld, M.B.B.S., M.B.A., M.P.H., of Royal Prince Alfred Hospital, New South Wales, Australia, and co-authors compared pregnancy outcomes for women who had kidney transplantation in childhood (less than 18 years of age; child-tx mothers) with women who had kidney transplantation in adulthood (18 years or older; adult-tx mothers).
The study results show that live births resulted from 76 percent of pregnancies in child-tx mothers and 77 percent of pregnancies in adult-tx mothers. The incidence of premature babies, that is, less than 37 weeks gestation was 45 percent in child-tx mothers and 53 percent in adult-tx mothers.
Authors identified a total of 101 pregnancies in 66 child-tx mothers and 626 pregnancies in 401 adult-tx mothers. At the time of pregnancy, the child-tx mothers were an average age of 25 and had a functioning transplant for 10 years, while adult-tx mothers were an average age of 31 with a functioning transplant for six years.
Preterm babies born to both sets of mothers were small for gestational age, 22 percent for child-tx mothers and 10 percent for adult-tx mothers. 57 percent term babies born to child-tx and 38 percent born to adult-tx mothers were frequently small for gestational age, both significantly more frequently than babies born at term in the general population.
The outcomes for child-tx mothers are similar to that of adult-tx mothers. The mothers and their physicians should be comforted that early onset of kidney failure and longer period of post transplant exposure to immuno-suppression do not adversely affect their pregnancy outcomes.
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