About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Women More Susceptible to Brain Damage from Alcohol Abuse

by VR Sreeraman on July 29, 2007 at 1:55 PM
Font : A-A+

Women More Susceptible to Brain Damage from Alcohol Abuse

Women are more prone to brain damage caused by alcohol abuse than men, a new study has found.

The study was conducted by a team of researchers led by Kristine Wiren at Oregon Health & Science University and the Portland Veterans Affairs Medical Center.

Advertisement

As part of the study researchers conducted experiments on mice to see the neuro-toxic effects of alcohol withdrawal by examining four groups of selectively bred mice: two female groups, including one prone to severe withdrawal and one resistant to severe withdrawal, and two similar male groups. Four control groups also were used.

Researchers used DNA microarray or 'gene chip' analysis, and examined 5,000 genes from the prefrontal cortex, the area of the brain implicated in complex planning, personality expression and social behaviour, and is involved in withdrawal-related brain circuitry.
Advertisement

They then identified a total of 295 alcohol-regulated genes for each mouse group.

"We're interested in that part of the brain because it's important in inhibitory control. Alcoholics are unable to display good inhibitory control," Wiren said.

Researchers examined cells in the lateral parietal cortex area, which is part of the network of brain regions, in addition to the prefrontal cortex, involved in inhibitory control, ten days after alcohol withdrawal, and identified live and dead cells with tissue stains.

The study found that female mice were more susceptible to neurotoxic effects of alcohol withdrawal, including significantly increased brain cell death, than male mice. It also found the gender difference exists whether the animals were prone to severe withdrawal due to a genetic predisposition, or resistant to it.

"At this one time point, which is the peak for cell death, we clearly see females are showing enhanced brain damage compared to the males. So, if you're female, the cells are dying; if you're a male, the cells are not," Wiren said.

Researchers noted that such brain damage might underlie debilitating cognitive dysfunction and motor deficits observed in some alcoholics. In addition, disruption of inhibitory functions in the prefrontal cortex might contribute to excessive drinking and the self-sustaining nature of alcoholism.

The findings of the study were published in the online edition of the journal Neuropsychopharmacology.

Source: ANI
SRM/C
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Turmeric: Magic Ingredient to Keep you Healthy in Winter
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Alcoholic Liver Disease Coma Parkinsons Disease Parkinsons Disease Surgical Treatment Alcoholism Cannabis Drug Abuse Alcohol and Driving Bubbles and Brews - Alcohol Facts Brain 

Recommended Reading
Alcohol abuse
Alcohol abuse...
Telephonic Counseling Can Help Drinkers Get Treatment
A recent study suggests that telephone counseling can be an effective tool in getting heavy ......
Drinking Problem Plagues 30% Americans
A new US study estimates that about 30 per cent of Americans report have some alcohol disorder at .....
Alcohol and Driving
Alcohol and driving do not mix. Drunken driving is the cause of many deaths in the world....
Alcoholic Liver Disease
Encyclopedia section of medindia gives general information about Alcoholic Liver Disease....
Alcoholism
Alcohol use disorder or alcoholism is an inability to control drinking. It can cause short term and ...
Bubbles and Brews - Alcohol Facts
There is more to alcohol than mere intoxication. Infamous because of its social abuse but indispensa...
Cannabis
Cannabis has a long history of medicinal, recreational, and industrial use and comes from a bushy pl...
Coma
Coma is a deep state of unconsciousness where the affected individual is alive but is not able to re...
Drug Abuse
The use of Drugs for reasons other than its prescribed recommendation, is known as Drug abuse or sub...
Parkinsons Disease
Parkinson’s disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use