About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Why Psoriasis Recurs?

by Vaishali Gokulakrishnan on September 30, 2017 at 5:00 PM
Font : A-A+

Why Psoriasis Recurs?

New research by investigators at Brigham and Women's Hospital and Rockefeller University helps address a longstanding question about the inflammatory skin condition psoriasis: Why do skin lesions that have resolved with therapy recur in the same locations after a patient stops using topical steroids?

According to BWH physician scientist Rachael Clark, MD, PhD, of the Department of Dermatology, researchers have been searching for years for a cell population that continues to smolder after psoriasis appears to resolve.

Advertisement


It's been challenging to zoom in on the population of T cells driving the disease in part because when psoriasis is active, lesions are flooded with diverse T cells.

But Clark and her colleagues have taken a new approach: instead of looking during the height of activity, they examined lesion sites after treatment, and identified T cell receptors of cells at these sites that were shared across psoriatic patients but not found in healthy individuals or those with other skin conditions.
Advertisement

The team's findings are reported in the Journal of Clinical Investigation.

"When psoriasis is treated, T cells that flooded in during inflammation recede like the tide," said Clark who is the corresponding author of the paper. "They leave behind a population of cells that stand out."

The population of T cells that remains are tissue resident memory cells, which live long term in skin and, when functioning properly, should be fighting infection.

But for patients with psoriasis, these cells may be the source of the misguided immune response that leads to red, inflamed patches on the skin.

To identify this T cell population, the researchers took biopsies at the sites of active lesions before treatment and biopsies of the same skin areas after the lesions had cleared on therapy.

Using high-throughput sequencing and immunostaining, the research team found that resolved lesions contained populations of T cells derived from just a few cells (known as oligoclonal populations) that produced IL-17, a telltale marker of inflammation. These cells also shared stretches of genetic sequence that code for the same antigen receptors.

These shared T cell antigen receptors were found only among cells from psoriatic patients, not in cells from healthy controls or people with skin conditions such as atopic dermatitis. This work highlights the fact that most psoriasis treatments do not kill these disease causing T cells but instead temporarily suppress their activation.

Now that they have identified the long lived, skin resident T cell population that appears to be driving recurrence, the team plans to search for new therapies that can deplete these resident T cells, potentially driving the disease into long term remission.

"We believe these resident memory T cells are the root of the problem. Imagine these cells are teenagers throwing a party. They invite lots of other cells to the site of the party, making it hard to identify them while the party is in full swing. It's only after inflammation dies down and everyone else goes home that we can see these culprits," said Clark.

"A small number of cells can cause so much trouble. But depleting this population of cells may be the key to slowing down this disease or preventing its recurrence."



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
January is the Thyroid Awareness Month in 2022
Menstrual Disorders
Coffee May Help You Fight Endometrial Cancer
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Psoriasis Dry Skin Symptom Evaluation Foods that are Bad for your Skin Itchy Scalp Diet for Psoriasis Scalp Psoriasis Psoriasis Cure with Homeopathy: Fact or Fiction Psoriatic Arthritis 

Recommended Reading
Biological Psoriasis Treatment Shows Good Efficacy in Clinical Trials
Psoriasis begins as a small scaling papule and they form scaling plaques. These plaques tend to ......
Currently Available Treatments are Not Sufficiently Treating Psoriasis Patients
A substantial part of people, one in five, undergoing systemic treatment for psoriasis still have .....
Psoriasis Patients Find Many Treatments, but Only Few Satisfied
Psoriasis takes a heavy emotional toll. There is no cure for psoriasis. Most people with psoriasis ....
Chronic Psoriasis Gets Breakthrough Targeted Therapy With Minimal Side Effects
New biological agent tildrakizumab successfully treats chronic psoriasis with minimal toxicity as .....
Diet for Psoriasis
Learn what causes psoriasis, the appropriate diet to follow and the importance of diet in the treatm...
Dry Skin Symptom Evaluation
Dry skin a result in inadequate hydration of the skin. This could be either due to a reduced intake...
Foods that are Bad for your Skin
Hydration, sebum formation and skin acidity determine the skin condition. Along with aging and envir...
Psoriasis
Psoriasis is a recurrent and complex inflammatory skin disorder that can have tremendous physical an...
Psoriasis Cure with Homeopathy: Fact or Fiction
Psoriasis, a chronic autoimmune skin disease has phases of exaggeration and remission. Homeopathic r...
Psoriatic Arthritis
Psoriatic arthritis is a kind of autoimmune inflammatory arthritis, which develops in 30 percent of ...
Scalp Psoriasis
Scalp psoriasis, a common skin disorder causes lesions on the scalp. There is no cure for scalp psor...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
CONSULT A DOCTOR
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)