A mutated gene called Catnap2 was found to be causing seizures in kids with autism. This is the first time scientists were able to identify the link between mutation and seizures, reveals a new study.
One third of children who have autism spectrum disorder also have epilepsy. It's related to a major autism risk gene, which is mutated in patients with autism. But scientists didn't now why the mutation, catnap2, caused seizures.
Autism
Autism is a neurodevelopmental disorder typically characterized by impaired social and communication skills combined with repetitive movements.
Advertisement
‘A new target for drugs has been found that helps in treating children with autism.’
Tweet it Now
Now Northwestern Medicine scientists have discovered the mutation acts like a bad gardener in the brain. It shrinks the neurons' tiny branches and leaves, its dendrite arbors and synapses that enable brain cells to relay vital messages and control the brain's activity. The shrinkage causes a breakdown in message delivery.
An important message that gets lost? Calm Down!
In people with the mutation, inhibitory neurons whose job is to keep things tranquil in the brain and slam the brake on excitatory neurons don't grow enough branches and leaves to communicate their Zen-like message, the scientists found. That leads to seizures.
![Study Uncovers How Toddlers With Autism Respond to Social Cues]( "Study Uncovers How Toddlers With Autism Respond to Social Cues")
Study finds the presence of alterations in information flow from brain areas involved in social cue processing in toddlers and pre-schoolers with Autism Spectrum Disorders (ASDs).
The mutation, CNTNAP2 or "catnap2," works as a team with another mutated gene, CASK, implicated in mental retardation. As a result, scientists have a new target for drugs to treat the disorder. The paper was published in Molecular Psychiatry.
"Now we can start testing drugs to treat the seizures as well as other problems in autism," said lead author Peter Penzes, the Ruth and Evelyn Dunbar Professor of Psychiatry and Behavioral Sciences at Northwestern University Feinberg School of Medicine.
"Patients with the mutation also have language delay and intellectual disability. So a drug targeting the mutation could have multiple benefits."
Next Penzes's team will do high-throughput screening of molecules with the goal of reversing these abnormalities in patients with autism.
Catnap2 is an adhesive molecule that helps cells stick together, in this case helping the synapses adhere to the dendrites. It's a difficult molecule to target with drugs, Penzes said.
But catnap2's partner, CASK, is a social butterfly enzyme that interacts with many other molecules. It can more easily be inhibited or activated with drugs.
Penzes's team will screen drugs to activate it because that appears to maintain healthy dendrite branches. When scientists blocked CASK in the study, dendrites didn't grow.
Source: Eurekalert
In people with the mutation, inhibitory neurons whose job is to keep things tranquil in the brain and slam the brake on excitatory neurons don't grow enough branches and leaves to communicate their Zen-like message, the scientists found. That leads to seizures.
Study Uncovers How Toddlers With Autism Respond to Social Cues
Study finds the presence of alterations in information flow from brain areas involved in social cue processing in toddlers and pre-schoolers with Autism Spectrum Disorders (ASDs).
Advertisement
The mutation, CNTNAP2 or "catnap2," works as a team with another mutated gene, CASK, implicated in mental retardation. As a result, scientists have a new target for drugs to treat the disorder. The paper was published in Molecular Psychiatry.
"Now we can start testing drugs to treat the seizures as well as other problems in autism," said lead author Peter Penzes, the Ruth and Evelyn Dunbar Professor of Psychiatry and Behavioral Sciences at Northwestern University Feinberg School of Medicine.
"Patients with the mutation also have language delay and intellectual disability. So a drug targeting the mutation could have multiple benefits."
Next Penzes's team will do high-throughput screening of molecules with the goal of reversing these abnormalities in patients with autism.
Catnap2 is an adhesive molecule that helps cells stick together, in this case helping the synapses adhere to the dendrites. It's a difficult molecule to target with drugs, Penzes said.
But catnap2's partner, CASK, is a social butterfly enzyme that interacts with many other molecules. It can more easily be inhibited or activated with drugs.
Penzes's team will screen drugs to activate it because that appears to maintain healthy dendrite branches. When scientists blocked CASK in the study, dendrites didn't grow.
Source: Eurekalert
Are Antipsychotic Drugs Safe for Autism Kids?
Children with intellectual difficulty or autism are more prone to Depression and Injury, finds a new study.
Advertisement
Advertisement
|
Advertisement
Recommended Readings
Latest Mental Health News
The Canadian government has launched 988, a new three-digit suicide crisis helpline to provide suicide prevention support.
Lactobacillus unveils new avenues for therapies targeting anxiety, depression, and various mental health conditions.
Neuroimaging exposes alterations in connectivity among individuals dealing with obsessive-compulsive disorder (OCD), stated study.
Proenkephalin, a chemical molecule present in the brain's hypothalamus, is linked to emotionally driven overeating in response to stress and threats.
Americans experience stress over the holidays, due to inflation, world affairs, rising flu and COVID-19 instances, and previous holiday melt-down.